| Age-associated changes in diastolic filling: Doppler E/A ratio is not associated with congestive heart failure in the elderly. | |
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MedLine Citation:
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PMID: 8023206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although left ventricular filling tends to occur in late diastole in the elderly, the clinical significance of this change is unclear. To determine the prevalence of diastolic filling delay and its relationship to congestive heart failure (CHF) in the elderly, we studied 114 community-living elderly volunteers (median age 75, 37% male). Clinical history, physical examination, chest x-ray film, and Doppler echocardiogram were obtained in blinded fashion. CHF was diagnosed by a previously validated clinico-radiographic scoring system. Diastolic filling was assessed by the Doppler ratio of early to late transmitral flow velocity (E/A). The standard clinical definition of diastolic filling delay (E/A < 1) was met by 94 subjects (82%), and median E/A was 0.72; for this study, diastolic filling delay was defined at the median, although both approaches yielded similar results. Systolic function was normal (ejection fraction > or = 0.5) in 97%. There were 22 subjects (19%) with definite or possible CHF. Older subjects were more likely to have CHF, but not more likely to have an E/A ratio below the median. Subjects with diastolic filling delay were no more likely to have CHF than those without. Mean E/A was not different between CHF groups, and there was no significant correlation between E/A and CHF score. There was still no association after controlling for age, history of hypertension, and other potential confounders by multiple logistic regression. Although diastolic filling delay is common in the elderly, it does not correlate with signs and symptoms of CHF. Determination of its prognostic significance requires a prospective follow-up study. |
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Authors:
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P R Marantz; J N Tobin; C A Derby; M V Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Southern medical journal Volume: 87 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-08-03 Completed Date: 1994-08-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 728-35 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Montefiore Medical Center, Bronx, NY. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Blood Flow Velocity Diastole / physiology* Echocardiography, Doppler* Female Heart Failure / physiopathology*, ultrasonography Humans Male Middle Aged Regression Analysis Risk Stroke Volume Ventricular Function, Left / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P01-AG-03949/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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