Document Detail


Age-associated changes in central nervous system glycerolipid composition and metabolism.
MedLine Citation:
PMID:  12512956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this review, changes in brain lipid composition and metabolism due to aging are outlined. The most striking changes in cerebral cortex and cerebellum lipid composition involve an increase in acidic phospholipid synthesis. The most important changes with respect to fatty acyl composition involve a decreased content in polyunsaturated fatty acids (20:4n-6, 22:4n-6, 22:6n-3) and an increased content in monounsaturated fatty acids (18:1n-9 and 20:1n-9), mainly in ethanolamine and serineglycerophospholipids. Changes in the activity of the enzymes modifying the phospholipid headgroup occur during aging. Serine incorporation into phosphatidylserine through base-exchange reactions and phosphatidylcholine synthesis through phosphatidylethanolamine methylation increases in the aged brain. Phosphatidate phosphohydrolase and phospholipase D activities are also altered in the aged brain thus producing changes in the lipid second messengers diacylglycerol and phosphatidic acid.
Authors:
N M Giusto; G A Salvador; P I Castagnet; S J Pasquaré; M G Ilincheta de Boschero
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neurochemical research     Volume:  27     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-01-06     Completed Date:  2003-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1513-23     Citation Subset:  IM    
Affiliation:
Instituto de Investigaciones Bioquímicas, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Cientificas y Técnicas, B8000FWB Bahía Blanca, Argentina. ngiusto@criba.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism*
Animals
Brain / metabolism*,  physiology
Glycerophospholipids / metabolism*
Rats
Chemical
Reg. No./Substance:
0/Glycerophospholipids

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