Document Detail

Age-associated changes of appetite-regulating peptides.
MedLine Citation:
PMID:  20590826     Owner:  NLM     Status:  MEDLINE    
Aging is associated with a progressive decrease in appetite and food intake. The reasons for the decline in food intake are multifactorial, and relate to both peripheral and central mechanisms. Current studies about the regulation of food intake suggest that there are many central mediators that control the appetite. To determine the mechanism of age-associated decrease in appetite and food intake, we focused on the age-associated changes of the suppressing and stimulatory effect of some appetite-regulating peptides. At first, we examined cholecystokinin (CCK), one of the typical appetite-suppressing factors. Although sensitivity to CCK is enhanced in old animals, the mechanism underlying this effect has not been elucidated. Next, we focused on the appetite-stimulating peptides, orexin-A, neuropeptide Y (NPY) and ghrelin, which are known to play a critical role in food intake. To determine the age-associated decrease in appetite and food intake, we compared the stimulatory effect of intracerebroventricular administration of orexin-A, NPY and ghrelin. We report the studies of the age-associated changes of appetite-regulating peptides in this review.
Saeko Akimoto; Kyoko Miyasaka
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Geriatrics & gerontology international     Volume:  10 Suppl 1     ISSN:  1447-0594     ISO Abbreviation:  Geriatr Gerontol Int     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135738     Medline TA:  Geriatr Gerontol Int     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  S107-19     Citation Subset:  IM    
Tokyo Metropolitan Institute of Gerontology, Tokyo Kasei University, Itabashiku, Tokyo, Japan.
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MeSH Terms
Aging / physiology*
Appetite / drug effects*,  physiology*
Blotting, Western
Cholecystokinin / physiology*
Eating / drug effects,  physiology
Ghrelin / administration & dosage,  physiology
Hypothalamus / metabolism
Intracellular Signaling Peptides and Proteins / administration & dosage,  physiology*
Neuropeptide Y / administration & dosage,  physiology*
Neuropeptides / administration & dosage,  physiology*
Rats, Wistar
Sympathomimetics / administration & dosage
Reg. No./Substance:
0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptide Y; 0/Neuropeptides; 0/Sympathomimetics; 0/orexins; 9011-97-6/Cholecystokinin

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