Document Detail

Age-associated cerebral atrophy in mouse lemur primates.
MedLine Citation:
PMID:  19564059     Owner:  NLM     Status:  MEDLINE    
We assessed the regional brain atrophy in mouse lemur primates from 4.7T T2-weighted magnetic resonance images. Thirty animals aged from 1.9 to 11.3 years were imaged. Sixty-one percent of the 23 animals older than 3 years involved in the study displayed an atrophy process. Cross-sectional analysis suggests that the atrophy follows a gradual pathway, starting in the frontal region then involving the temporal and/or the parietal part of the brain and finally the occipital region. Histological evaluation of five animals selected according to various stages of atrophy suggested that extracellular amyloid deposits and tau pathology cannot explain by themselves this atrophy and that intracellular amyloid deposition is more closely linked to this pathology. This study suggests that most of the age-related atrophy occurring in mouse lemurs is caused by one clinical, evolving, pathological process. The ability to follow this pathology non-invasively by MRI will allow to further characterize it and evaluate its relationship with neuropathological lesions that are involved in human diseases such as Alzheimer.
Audrey Kraska; Olene Dorieux; Jean-Luc Picq; Fanny Petit; Emmanuel Bourrin; Evelyne Chenu; Andreas Volk; Martine Perret; Philippe Hantraye; Nadine Mestre-Frances; Fabienne Aujard; Marc Dhenain
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-06-28
Journal Detail:
Title:  Neurobiology of aging     Volume:  32     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-08-17     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  894-906     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Inc. All rights reserved.
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MeSH Terms
Aging / pathology*
Atrophy / pathology
Brain / pathology*
Magnetic Resonance Imaging
Plaque, Amyloid / pathology
tau Proteins / physiology
Grant Support
R01 AG020197/AG/NIA NIH HHS; R01 AG020197-06A2/AG/NIA NIH HHS; R01 AG020197-07/AG/NIA NIH HHS; R01-AG020197/AG/NIA NIH HHS
Reg. No./Substance:
0/tau Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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