|Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.|
|PMID: 23105044 Owner: NLM Status: MEDLINE|
|BACKGROUND: Age trends in estradiol and estrone levels in men and how lifestyle factors, comorbid conditions, testosterone, and sex hormone-binding globulin affect these age trends remain poorly understood, and were examined in men of the Framingham Heart Study.
METHODS: Estrone and estradiol concentrations were measured in morning fasting samples using liquid chromatography tandem mass spectrometry in men of Framingham Offspring Generation. Free estradiol was calculated using a law of mass action equation.
RESULTS: There were 1,461 eligible men (mean age [±SD] 61.1±9.5 years and body mass index [BMI] 28.8±4.5kg/m(2)). Total estradiol and estrone were positively associated with age, but free estradiol was negatively associated with age. Age-related increase in total estrone was greater than that in total estradiol. Estrone was positively associated with smoking, BMI, and testosterone, and total and free estradiol with diabetes, BMI, testosterone, and comorbid conditions; additionally, free estradiol was associated negatively with smoking. Collectively, age, BMI, testosterone, and other health and behavioral factors explained only 18% of variance in estradiol, and 9% of variance in estrone levels. Men in the highest quintile of estrone levels had significantly higher age and BMI, and a higher prevalence of smoking, diabetes, and cardiovascular disease than others, whereas those in the highest quintile of estradiol had higher BMI than others.
CONCLUSIONS: Total estrone and estradiol levels in men, measured using liquid chromatography tandem mass spectrometry, revealed significant age-related increases that were only partially accounted for by cross-sectional differences in BMI, diabetes status, and other comorbidities and health behaviors. Longitudinal studies are needed to confirm these findings.
|Guneet Kaur Jasuja; Thomas G Travison; Maithili Davda; Joanne M Murabito; Shehzad Basaria; Anqi Zhang; Mark M Kushnir; Alan L Rockwood; Wayne Meikle; Michael J Pencina; Andrea Coviello; Adam J Rose; Ralph D'Agostino; Ramachandran S Vasan; Shalender Bhasin|
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|Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-25|
|Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 68 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2013 Jun|
|Created Date: 2013-05-22 Completed Date: 2013-08-15 Revised Date: 2014-03-19|
Medline Journal Info:
|Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States|
|Languages: eng Pagination: 733-40 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Aging / blood*
Alcohol Drinking / adverse effects
Biological Markers / blood
Body Mass Index
Boston / epidemiology
Cardiovascular Diseases / epidemiology
Chromatography, Liquid* / methods
Diabetes Complications / epidemiology
Estradiol / blood*
Estrogens / blood*
Estrone / blood*
Obesity / blood*, epidemiology
Sex Hormone-Binding Globulin / metabolism
Smoking / adverse effects
Tandem Mass Spectrometry* / methods
Testosterone / blood
|1R01AG31206/AG/NIA NIH HHS; 5P30AG031679/AG/NIA NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; R01 DK092938/DK/NIDDK NIH HHS|
|0/Biological Markers; 0/Estrogens; 0/Sex Hormone-Binding Globulin; 2DI9HA706A/Estrone; 3XMK78S47O/Testosterone; 4TI98Z838E/Estradiol|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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