Document Detail

Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.
MedLine Citation:
PMID:  23105044     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Age trends in estradiol and estrone levels in men and how lifestyle factors, comorbid conditions, testosterone, and sex hormone-binding globulin affect these age trends remain poorly understood, and were examined in men of the Framingham Heart Study.
METHODS: Estrone and estradiol concentrations were measured in morning fasting samples using liquid chromatography tandem mass spectrometry in men of Framingham Offspring Generation. Free estradiol was calculated using a law of mass action equation.
RESULTS: There were 1,461 eligible men (mean age [±SD] 61.1±9.5 years and body mass index [BMI] 28.8±4.5kg/m(2)). Total estradiol and estrone were positively associated with age, but free estradiol was negatively associated with age. Age-related increase in total estrone was greater than that in total estradiol. Estrone was positively associated with smoking, BMI, and testosterone, and total and free estradiol with diabetes, BMI, testosterone, and comorbid conditions; additionally, free estradiol was associated negatively with smoking. Collectively, age, BMI, testosterone, and other health and behavioral factors explained only 18% of variance in estradiol, and 9% of variance in estrone levels. Men in the highest quintile of estrone levels had significantly higher age and BMI, and a higher prevalence of smoking, diabetes, and cardiovascular disease than others, whereas those in the highest quintile of estradiol had higher BMI than others.
CONCLUSIONS: Total estrone and estradiol levels in men, measured using liquid chromatography tandem mass spectrometry, revealed significant age-related increases that were only partially accounted for by cross-sectional differences in BMI, diabetes status, and other comorbidities and health behaviors. Longitudinal studies are needed to confirm these findings.
Guneet Kaur Jasuja; Thomas G Travison; Maithili Davda; Joanne M Murabito; Shehzad Basaria; Anqi Zhang; Mark M Kushnir; Alan L Rockwood; Wayne Meikle; Michael J Pencina; Andrea Coviello; Adam J Rose; Ralph D'Agostino; Ramachandran S Vasan; Shalender Bhasin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-25
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  68     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-22     Completed Date:  2013-08-15     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  733-40     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Aging / blood*
Alcohol Drinking / adverse effects
Biological Markers / blood
Body Mass Index
Boston / epidemiology
Cardiovascular Diseases / epidemiology
Chromatography, Liquid* / methods
Cohort Studies
Diabetes Complications / epidemiology
Estradiol / blood*
Estrogens / blood*
Estrone / blood*
Independent Living
Life Style
Middle Aged
Obesity / blood*,  epidemiology
Risk Factors
Sex Hormone-Binding Globulin / metabolism
Smoking / adverse effects
Tandem Mass Spectrometry* / methods
Testosterone / blood
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Estrogens; 0/Sex Hormone-Binding Globulin; 2DI9HA706A/Estrone; 3XMK78S47O/Testosterone; 4TI98Z838E/Estradiol

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