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Age Trajectories of Stroke Case Fatality: Leveling Off at the Highest Ages.
MedLine Citation:
PMID:  21346579     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:: Mortality rates level off at older ages. Age trajectories of stroke case-fatality rates were studied with the aim of investigating prevalence of this phenomenon, specifically in case-fatality rates at older ages. METHODS:: A registry of all hospitalized stroke patients in Denmark included 40,155 patients with evaluations of stroke severity, computed tomography, and cardiovascular risk factors. Data on mortality were used to construct age trajectories of 3-day, 1-week, 1-month, and 1-year case-fatality rates in men and women. RESULTS:: Of the 40,155 patients, 19,301 (48%) were women (mean age, 74.5 years) and 20,854 (52%) were men (mean age, 69.7 years). In both women and men, 3-day case-fatality rates leveled off, beginning in the patients' mid-70s. In women, 1-week case-fatality rates leveled off further in their early 80s, whereas in men, 1-week case-fatality rates accelerated with age. One-month and 1-year case-fatality rates accelerated with age for both sexes. CONCLUSIONS:: It is an apparent paradox that case-fatality rates in the acute state of stroke level off at the highest ages. Heterogeneity, innate or acquired, in regard to survival capacity may explain the phenomenon.
Authors:
Tom Skyhøj Olsen; Zorana Jovanovic Andersen; Klaus Kaae Andersen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-21
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  -     ISSN:  1531-5487     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the aThe Stroke Unit, Frederiksberg Hospital, Frederiksberg, Denmark; and bInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
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