Document Detail


Age-specific effects of voluntary exercise on memory and the older brain.
MedLine Citation:
PMID:  22795967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Physical exercise in early adulthood and mid-life improves cognitive function and enhances brain plasticity, but the effects of commencing exercise in late adulthood are not well-understood.
METHOD: We investigated the effects of voluntary exercise in the restoration of place recognition memory in aged rats and examined hippocampal changes of synaptic density and neurogenesis.
RESULTS: We found a highly selective age-related deficit in place recognition memory that is stable across retest sessions and correlates strongly with loss of hippocampal synapses. Additionally, 12 weeks of voluntary running at 20 months of age removed the deficit in the hippocampally dependent place recognition memory. Voluntary running restored presynaptic density in the dentate gyrus and CA3 hippocampal subregions in aged rats to levels beyond those observed in younger animals, in which exercise had no functional or synaptic effects. By contrast, hippocampal neurogenesis, a possible memory-related mechanism, increased in both young and aged rats after physical exercise but was not linked with performance in the place recognition task. We used graph-based network analysis based on synaptic covariance patterns to characterize efficient intrahippocampal connectivity. This analysis revealed that voluntary running completely reverses the profound degradation of hippocampal network efficiency that accompanies sedentary aging. Furthermore, at an individual animal level, both overall hippocampal presynaptic density and subregional connectivity independently contribute to prediction of successful place recognition memory performance.
CONCLUSIONS: Our findings emphasize the unique synaptic effects of exercise on the aged brain and their specific relevance to a hippocampally based memory system for place recognition.
Authors:
Joyce Siette; R Frederick Westbrook; Carl Cotman; Kuldip Sidhu; Wanlin Zhu; Perminder Sachdev; Michael J Valenzuela
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-15
Journal Detail:
Title:  Biological psychiatry     Volume:  73     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-12     Completed Date:  2013-07-26     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  435-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Brain / metabolism,  physiology*
Brain-Derived Neurotrophic Factor / metabolism
Female
Hippocampus / metabolism
Maze Learning / physiology*
Memory / physiology*
Nerve Net / metabolism,  physiology*
Neurogenesis / physiology*
Physical Conditioning, Animal / physiology,  psychology*
Rats
Running
Grant Support
ID/Acronym/Agency:
AG00538/AG/NIA NIH HHS; P01 AG000538/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor
Comments/Corrections

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