Document Detail


Age-Specific 99th Percentile Cutoff of High-Sensitivity Cardiac Troponin T for Early Prediction of Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) in Middle-Aged Patients.
MedLine Citation:
PMID:  24375759     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) assay is used in the diagnosis and risk assessment of patients with symptoms of myocardial infarction. This study was undertaken to establish an age-specific 99th percentile cutoff value for hs-cTnT in Chinese population, and to evaluate its potential for early prediction of non-ST-segment elevation myocardial infarction (NSTEMI) in middle-aged patients.
METHODS: Troponin T levels in blood obtained from healthy Chinese adults were assayed using hs-cTnT. The distribution was plotted and 99th percentiles were determined by nonparametric statistics. Prediction performance at the conventional cutoff (14 ng/L) recommended by the Roche company was compared with the age-specific cutoff for NSTEMI in 100 middle-aged patients (40-60 years of age) with acute chest pain.
RESULTS: The 99th percentile for hs-cTnT was 14 ng/L for patients ≥60 years of age and 11 ng/L for those <60. Fifty of the 100 patients were finally diagnosed with NSTEMI. The age-specific 99th percentile cutoff value of 11 ng/L identified a higher number of patients with NSTEMI than the conventional 14 ng/L cutoff (46 vs. 40 patients), although the difference was not statistically significant (P = 0.084). In addition, the sensitivity of hs-cTnT increased from 80 to 92% and the negative predictive values increased from 82.4 to 91.8%.
CONCLUSION: Using 11 ng/L as a decision-making cutoff point for hs-cTnT facilitated earlier prediction of NSTEMI in middle-aged patients than the conventional 14 ng/L cutoff. Further studies are needed to confirm this finding in larger group of patients.
Authors:
Lie Ying Fan; Ping Yu; Shan Shan Yu; Yu Ying Gu; Ming Zong; Ying Cai; Zhong Min Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-27
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  -     ISSN:  1098-2825     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Wiley Periodicals, Inc.
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