Document Detail


Age-related macular degeneration and long-term risk of stroke subtypes.
MedLine Citation:
PMID:  22535267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: We examined the relationship of age-related macular degeneration (AMD) with incident stroke, including stroke subtypes of cerebral infarction and intracerebral hemorrhage.
METHODS: We included 12 216 participants with retinal photographs taken at the third examination visit (1993-1995) from the Atherosclerosis Risk in Communities (ARIC) Study, a population-based cohort study in middle-aged persons. Images were evaluated for AMD signs according to a standardized protocol. Incident events of stroke and its subtypes were identified and validated through case record review over time.
RESULTS: AMD was diagnosed in 591 participants, of whom 576 had early and 15 late AMD. After a mean follow-up of 13.0 years (SD, 3.3), 619 persons developed an incident stroke, including 548 cerebral infarction and 57 intracerebral hemorrhages. Participants with any AMD were at an increased risk of stroke (multivariable adjusted hazard ratio, 1.51; 95% CI, 1.11-2.06) with a stronger association for intracerebral hemorrhage (hazard ratio, 2.64; 95% CI, 1.18-5.87) than cerebral infarction (hazard ratio, 1.42; 95% CI, 1.01-1.99).
CONCLUSIONS: Persons with AMD are at an increased risk of both cerebral infarction and intracerebral hemorrhage. These data provide further insight into common pathophysiological processes between AMD and stroke subtypes.
Authors:
M Kamran Ikram; Paul Mitchell; Ronald Klein; A Rickey Sharrett; David J Couper; Tien Y Wong
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2012-04-24
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  43     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-08-16     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1681-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cerebral Hemorrhage / epidemiology*,  etiology,  physiopathology
Cerebral Infarction / epidemiology*,  etiology,  physiopathology
Female
Follow-Up Studies
Humans
Incidence
Macular Degeneration / complications,  epidemiology*,  physiopathology
Male
Middle Aged
Risk Factors
Stroke / epidemiology*,  etiology,  physiopathology
Time Factors
Grant Support
ID/Acronym/Agency:
HHSN268201100005C/HL/NHLBI NIH HHS; HHSN268201100006C/HL/NHLBI NIH HHS; HHSN268201100007C/HL/NHLBI NIH HHS; HHSN268201100008C/HL/NHLBI NIH HHS; HHSN268201100009C/HL/NHLBI NIH HHS; HHSN268201100010C/HL/NHLBI NIH HHS; HHSN268201100011C/HL/NHLBI NIH HHS; HHSN268201100012C/HL/NHLBI NIH HHS; U01 HL096812/HL/NHLBI NIH HHS
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