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Age and Gender Substantially Influence the Relationship Between Thyroid Status and the Lipoprotein Profile: Results from a Large Cross-Sectional Study.
MedLine Citation:
PMID:  22861525     Owner:  NLM     Status:  Publisher    
Background Conflicting data are reported on the association between mild thyroid failure and lipid profile, primarily regarding serum triglyceride values and patients with slightly elevated TSH (<10 mIU/l). In this study, we assessed the possible influence of gender and age on this relationship. Methods The study included 2308 consecutive patients who were seen for suspected or diagnosed thyroid disease (1874 F, 434 M, mean age 47.5±14.1 and 46.9±14.0 years, respectively) who had studies of thyroid status and lipoprotein profile after an overnight fast. Patients with uncontrolled diabetes mellitus and those taking lipid-lowering drugs were excluded. Results. 628 patients receiving L-thyroxin had already a diagnosis of hypothyroidism: 200 were hyperthyroid and 120 still hypothyroid. Overall, 648 patients resulted hypothyroid and 290 hyperthyroid. No gender difference in the frequency of TSH values in the ranges studied (i.e. TSH frequency distribution) was observed. Total cholesterol (TC) and LDL cholesterol (LDLc) values (p<0.0003 and p<0.003, respectively) as well as the LDL/HDLc ratio (p<0.03) were elevated in unselected women with TSH values in the 4th TSH group (>10 mIU/l) but also in those of the 3rd group (3.6<TSH<10.0 mIU/l) older than 50 years (TC and LDLc p=0.01, LDL/HDLc ratio p=0.02 Vs euthyroid women). Among unselected men only those of the 4th TSH group had elevated triglyceride (p<0.0001) but not cholesterol values. However, men of the 3rd and 4th TSH group older than 65 years had significantly higher TC, LDLc and LDL/HDLc values too (p=0.03, p=0.02 and p=0.01, respectively Vs euthyroid men). In the final model of stepwise regression for predicting each lipid parameter variation on the basis of age, TSH, FT4, and body mass index (BMI) analysis, age had the highest standardized coefficient (0.36 and 0.37, respectively), followed by TSH (0.20 and 0.11, respectively) and FT4 (-0.11 and -0.09, respectively) looking at TC and LDLc whereas, BMI had the highest standardized coefficient (0.28), followed by age (0.15) and TSH (0.11) looking at triglyceride variation. Conclusions This study confirms a gender differentiation in the relationship between hypothyroidism and lipid profile, which is substantially influenced by age, especially in patients with mild thyroid impairment (TSH<10 mIU/l).
Sara Tognini; Antonio Polini; Giuseppe Pasqualetti; Silvia Ursino; Nadia Caraccio; Marco Ferdeghini; Fabio Monzani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-4
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  -     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Pisa, Internal Medicine, Pisa, Italy;
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