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Age- and Gender-Specific Reference Intervals for Serum Lipid Levels in School Children Measured with an Advia 1650 Chemistry Analyzer.
MedLine Citation:
PMID:  21418404     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Due to the lack of country-specific norms in Saudi Arabia, age- and gender-specific lipid reference intervals needs to be established for Saudi children. METHODS: Blood samples were collected from 1168 children aged 6 to 16 years, 500 (43%) boys and 668 (57%) girls and were analyzed for cholesterol, HDL and LDL. Reference intervals were established by calculating the mean and the 2.5(th) and 97.5(th) percentiles. RESULTS: There were significant differences between males at each Tanner stages with respect to cholesterol (p < 0.001), and HDL (p < 0.0001) but not LDL (p < 0.06) among females. There were significant differences between boys and girls during puberty age with respect to cholesterol (p < 0.0001), HDL (p < 0.0001), and LDL (p < 0.001). There was a significant positive correlation between total cholesterol levels, LDL and HDL levels at all Tanner stages in both genders. In females, the only significant inverse correlation was at stage I (r = -0.243, p = 0.001), there was no significant correlation at other stages. CONCLUSIONS: Unlike children in other developing countries, Saudi children do not have lower serum cholesterol than their Western counterparts. We believe that these findings reflect changing dietary habits and increasing affluence in Saudi Arabia. These reference intervals may be used to aid in the early assessment of cardiovascular risk in Saudi pediatric populations.
Authors:
Waleed Tamimi; Hani Tamim; Naila Felimban; Angham Almutair; Yasmin Altwaijri; Ibrahim Alalwan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-21
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.
Affiliation:
Department of Pathology & Laboratory Medicine, College of Medicine, Pediatric Endocrinology Department, College of Medicine King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia. Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
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