Document Detail


Age- and ethnic-specific elevation of ALT among obese children at risk for nonalcoholic steatohepatitis (NASH): implications for screening.
MedLine Citation:
PMID:  18832535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objectives are to: (1) characterize ethnic-specific differences in alanine aminotransferase (ALT) elevation among obese children, (2) investigate the earliest ages at which significant ALT elevation occurs, and (3) determine associations between ALT and biochemical parameters. A cohort of 134 multiethnic obese children and adolescents was analyzed retrospectively. ALT levels > or =45 U/L or <45 U/L, denoting high or normal risk, were used to categorize obese children's risk for developing nonalcoholic steatohepatitis. In all, 60% of Hispanics had high-risk ALT levels compared with 12% of whites and 8% of blacks. A significantly higher proportion of boys had ALT > or = 45 U/L (49.4%, vs 37.9% for girls, P = .002); 17.5% were Hispanic boys less than 7 years old. Obese Hispanic children, particularly boys, not only have higher ALT levels but present alarmingly young with high-risk levels. This study highlights a discrete subgroup of children who may present with fatty liver at a younger age and should be screened earlier.
Authors:
Daniel H Leung; Kent Williams; J Kennard Fraley; William J Klish
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Publication Detail:
Type:  Journal Article     Date:  2008-10-02
Journal Detail:
Title:  Clinical pediatrics     Volume:  48     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-7     Citation Subset:  AIM; IM    
Affiliation:
Children's Hospital of Philadelphia, Department of Gastroenterology, Hepatology, and Nutrition, Pennsylvania 19104, USA. leungd@email.chop.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
African Continental Ancestry Group
Age Factors
Alanine Transaminase / blood*
Child
Child, Preschool
Ethnic Groups
European Continental Ancestry Group
Fatty Liver / etiology*
Female
Hispanic Americans
Humans
Male
Obesity / complications,  enzymology*
Young Adult
Chemical
Reg. No./Substance:
EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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