Document Detail


Age-dependent effects of ELF-MF on oxidative stress in the brain of Mongolian gerbils.
MedLine Citation:
PMID:  23292355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of study was to investigate the effects of extremely low frequency magnetic field (ELF-MF; 50 Hz; 0.1, 0.25 and 0.5 mT) on oxidative stress in the brain of 3- (adult) and 10-month-old (middle-aged) gerbils. Nitric oxide (NO) level, superoxide (O2(-)) production, superoxide dismutase (SOD) activity, and index of lipid peroxidation (ILP) were measured in the forebrain cortex, striatum, hippocampus, and cerebellum immediately and 3 days after cessation of 7-day exposure. In all gerbils, ELF-MF significantly increased oxidative stress in all tested brain regions. This effect was correlated with the value of magnetic induction and was higher in middle-aged gerbils. Three days after cessation of exposure, the values of examined parameters were closer to control levels. In adult gerbils, the effect of ELF-MF of 0.1 mT on NO level, O2(-) production and SOD activity was almost fully disappeared, and ILP was at the control level regardless of the value of magnetic induction. In middle-aged gerbils, the effect of ELF-MF was still present but to a lesser degree than those observed immediately after cessation of exposure. These findings pointed out the ability of ELF-MF to induce age- and magnetic induction-dependent modification of oxidative stress in the brain.
Authors:
Vesna Selaković; Snežana Rauš Balind; Lidija Radenović; Zlatko Prolić; Branka Janać
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biochemistry and biophysics     Volume:  66     ISSN:  1559-0283     ISO Abbreviation:  Cell Biochem. Biophys.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-30     Completed Date:  2014-03-03     Revised Date:  2014-03-17    
Medline Journal Info:
Nlm Unique ID:  9701934     Medline TA:  Cell Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  513-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism*
Animals
Brain / metabolism*
Gerbillinae
Lipid Peroxidation
Magnetic Fields*
Male
Nitric Oxide / biosynthesis
Oxidative Stress*
Superoxide Dismutase / metabolism
Superoxides / metabolism
Time Factors
Chemical
Reg. No./Substance:
11062-77-4/Superoxides; 31C4KY9ESH/Nitric Oxide; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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