Document Detail


Age attenuates leucine oxidation after eccentric exercise.
MedLine Citation:
PMID:  23325713     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aging may alter protein metabolism during periods of metabolic and physiologic challenge. The purpose of this study was to assess the effects of age on whole-body amino acid turnover in response to eccentric exercise and hyperglycemia-induced hyperinsulinemia. 16 healthy men were divided into young (N=8) and older (N=8) groups. Protein metabolism was assessed using a [1-13C]-leucine isotopic tracer approach. Measures were obtained under fasted basal conditions and during 3-h hyperglycemic clamps that were performed without (control) and 48 h after eccentric exercise. Exercise reduced leucine oxidation in the younger men (P<0.05), but not in older men. Insulin sensitivity was inversely correlated with leucine oxidation (P<0.05), and was lower in older men (P<0.05). Healthy aging is associated with an impaired capacity to adjust protein oxidation in response to eccentric exercise. The decreased efficiency of protein utilization in older men may contribute to impaired maintenance, growth, and repair of body tissues with advancing age.
Authors:
E L Kullman; W W Campbell; R K Krishnan; K E Yarasheski; W J Evans; J P Kirwan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-16
Journal Detail:
Title:  International journal of sports medicine     Volume:  34     ISSN:  1439-3964     ISO Abbreviation:  Int J Sports Med     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-31     Completed Date:  2014-03-05     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  695-9     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aging / physiology*
Exercise / physiology*
Exercise Test / methods
Glucose Clamp Technique
Humans
Hyperglycemia / metabolism
Insulin Resistance / physiology*
Leucine / metabolism*
Male
Middle Aged
Oxidation-Reduction
Time Factors
Young Adult
Grant Support
ID/Acronym/Agency:
AG11811/AG/NIA NIH HHS; AG12834/AG/NIA NIH HHS; AG15385/AG/NIA NIH HHS; DK020579/DK/NIDDK NIH HHS; DK056341/DK/NIDDK NIH HHS; P30 DK020579/DK/NIDDK NIH HHS; P30 DK056341/DK/NIDDK NIH HHS; P41 GM103422/GM/NIGMS NIH HHS; P41 RR000954/RR/NCRR NIH HHS; R01 AG012834/AG/NIA NIH HHS; R01 AG015385/AG/NIA NIH HHS; RR000954/RR/NCRR NIH HHS; RR000954,/RR/NCRR NIH HHS; T32 DK007319/DK/NIDDK NIH HHS; T32DK007319/DK/NIDDK NIH HHS; U24 DK076174/DK/NIDDK NIH HHS; UL1 TR000439/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
GMW67QNF9C/Leucine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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