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Age Associated Communication Between Cells and Matrix: A Potential Impact on Stem Cell-Based Tissue Regeneration Strategies.
MedLine Citation:
PMID:  25482504     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract A recent paper demonstrated that decellularized extracellular matrix (DECM) deposited by synovium-derived stem cells (SDSCs), especially from fetal donors, could rejuvenate human adult SDSCs in both proliferation and chondrogenic potential, in which expanded cells and corresponding culture substrate (such as DECM) were found to share a mutual reaction in both elasticity and protein profiles (see ref. 1). It seems that young DECM may assist in the development of culture strategies that optimize proliferation and maintain "stemness" of mesenchymal stem cells (MSCs), helping to overcome one of the primary difficulties in MSC-based regenerative therapies. In this paper, the effects of age on the proliferative capacity and differentiation potential of MSCs are reviewed, along with the ability of DECM from young cells to rejuvenate old cells. In an effort to highlight some of the potential molecular mechanisms responsible for this phenomenon, we discuss age-related changes to extracellular matrix (ECM)'s physical properties and chemical composition.
Authors:
Kevin Lynch; Ming Pei
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-6
Journal Detail:
Title:  Organogenesis     Volume:  -     ISSN:  1555-8592     ISO Abbreviation:  Organogenesis     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-8     Completed Date:  -     Revised Date:  2014-12-9    
Medline Journal Info:
Nlm Unique ID:  101253266     Medline TA:  Organogenesis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
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