Document Detail

After eight-year-tolerance minimal i.v. anti-D infusions unleash hemolysis in a patient with immune thrombocytopenic purpura (ITP).
MedLine Citation:
PMID:  15062747     Owner:  NLM     Status:  MEDLINE    
Minimal doses of i.v. anti-D for ITP are not exempt from the risk of intravascular hemolysis, a rare potentially severe short-lived post-infusion complication. We report here on an elderly woman with chronic pancytopenia and splenomegaly in whom bleeding manifestations ceased after i.v. anti-Rh(D) immunoglobulin minidoses replaced long-term conventional treatment for immune thrombocytopenic purpura. Anti-Rh(D) infusions, that had been well tolerated for eight years, became the main culprit in triggering of disproportionate hemolysis. In spite of in crescendo complication, the anti-Rh(D) immunoglobulin schedule was maintained for another six months. With no further treatment, the patient's health remains stable 20 months later.
M D Enrique Rewald; M M Francischetti
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis     Volume:  30     ISSN:  1473-0502     ISO Abbreviation:  Transfus. Apher. Sci.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-11-19     Revised Date:  2006-06-07    
Medline Journal Info:
Nlm Unique ID:  101095653     Medline TA:  Transfus Apher Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  T    
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MeSH Terms
Infusions, Intravenous
Isoantibodies / administration & dosage*
Platelet Count
Purpura, Thrombocytopenic, Idiopathic / blood*,  immunology*
Rho(D) Immune Globulin / administration & dosage*,  adverse effects*
Time Factors
Reg. No./Substance:
0/Isoantibodies; 0/RHO(D) antibody; 0/Rho(D) Immune Globulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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