Document Detail

African Burkitt lymphoma: age-specific risk and correlations with malaria biomarkers.
MedLine Citation:
PMID:  21363976     Owner:  NLM     Status:  MEDLINE    
African Burkitt lymphoma is an aggressive B-cell, non-Hodgkin lymphoma linked to Plasmodium falciparum malaria. Malaria biomarkers related to onset of African Burkitt lymphoma are unknown. We correlated age-specific patterns of 2,602 cases of African Burkitt lymphoma (60% male, mean ± SD age = 7.1 ± 2.9 years) from Uganda, Ghana, and Tanzania with malaria biomarkers published from these countries. Age-specific patterns of this disease and mean multiplicity of P. falciparum malaria parasites, defined as the average number of distinct genotypes per positive blood sample based on the merozoite surface protein-2 assessed by polymerase chain reaction, were correlated and both peaked between 5 and 9 years. This pattern, which was strong and consistent across regions, contrasted parasite prevalence, which peaked at 2 years and decreased slightly, and geometric mean parasite density, which peaked between 2 and 3 years and decreased sharply. Our findings suggest that concurrent infection with multiple malaria genotypes may be related to onset of African Burkitt lymphoma.
Benjamin Emmanuel; Esther Kawira; Martin D Ogwang; Henry Wabinga; Josiah Magatti; Francis Nkrumah; Janet Neequaye; Kishor Bhatia; Glen Brubaker; Robert J Biggar; Sam M Mbulaiteye
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  84     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-04-28     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  AIM; IM    
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852, USA.
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MeSH Terms
Age Factors
Biological Markers / blood
Burkitt Lymphoma / epidemiology*,  etiology*
Child, Preschool
Ghana / epidemiology
Infant, Newborn
Malaria, Falciparum / complications*,  genetics
Middle Aged
Risk Factors
Tanzania / epidemiology
Time Factors
Uganda / epidemiology
Young Adult
Grant Support
N01-CO-12400/CO/NCI NIH HHS; N02-CP-31003/CP/NCI NIH HHS
Reg. No./Substance:
0/Biological Markers

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