Document Detail


Aflatoxin-impaired ability to accumulate oxycarotenoid pigments during restoration in young chickens.
MedLine Citation:
PMID:  3405939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism by which aflatoxin causes paling in chickens was investigated by measuring its effect on the restoration of pigments in 3-wk-old birds made pale by feeding a white corn-soy diet. Pigment restoration was accomplished by feeding the same diet supplemented with lutein (70 micrograms/g of diet), which is the major oxycarotenoid pigment in chicken diets and tissues. The oxycarotenoids (free, monoester, and diester forms of lutein) in the toe web, liver, serum, and jejunal mucosa of control and aflatoxin-fed (2 micrograms/g of diet) birds were measured by HPLC at 0, 1, 2, 3, 6, and 9 days of repletion. Aflatoxin caused a significant (P less than .05) depression of all forms of lutein in the toe web. In the liver, aflatoxin decreased lutein significantly (P less than .05) but increased lutein monoester and lutein diester. Lutein accumulation in serum and mucosa were inhibited significantly (P less than .05) starting on Days 2 and 3, respectively. These data imply that the normal accumulation of lutein from the diet proceeded into and through the mucosa to the serum to depot sites in the liver and integument, where lutein was acylated to its monoester, which was acylated to its diester. Further, aflatoxin inhibited, apparently independently, the accumulation of lutein by the mucosa, serum, liver, and integument. Pharmacokinetic analysis of the data indicated that both acylation steps in the integument were sensitive to aflatoxin, but the passage of lutein from serum into the integument was not affected.
Authors:
J L Schaeffer; J K Tyczkowski; J E Riviere; P B Hamilton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Poultry science     Volume:  67     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-09-19     Completed Date:  1988-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  619-25     Citation Subset:  IM    
Affiliation:
Department of Poultry Science, School of Veterinary Medicine, North Carolina State University, Raleigh 27695-7608.
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MeSH Terms
Descriptor/Qualifier:
Aflatoxins / pharmacology*
Animals
Carotenoids / metabolism*
Chickens / metabolism*
Male
Pigmentation Disorders / chemically induced,  metabolism,  veterinary*
Poultry Diseases / chemically induced*,  metabolism
Skin Pigmentation / drug effects*
Chemical
Reg. No./Substance:
0/Aflatoxins; 36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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