| Aflatoxin B1-induced injury in monkeys. | |
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MedLine Citation:
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PMID: 6893915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short-term effects of small doses of aflatoxin (0.05 mg/kg of body weight twice a week) were studied in rhesus monkeys fed low-protein and high-protein diets. Animals on high- and low-protein diets without aflatoxin administration served as controls. There was no difference in weight gain, hemogram, serum protein levels, and liver function test results between aflatoxin-treated and control animals. However, morphological alterations in hepatocytes in the form of mild degenerative changes, focal areas of necrosis, and increased regenerative activity were seen in the aflatoxin-treated monkeys. Data on cell cycle analysis done by DNA content estimation through microfluorimetry on DNA-fluorescent, acriflavin-stained liver imprints revealed larger number of cells in the S and Gi2 phases in animals given aflatoxin. However, the changes in cell cycle, as well as in morphology, were more marked in the aflatoxin-treated, low-protein-diet group. |
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Authors:
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V Singhal; M Mathur; V Ramalingaswami; M G Deo |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 105 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-03-27 Completed Date: 1981-03-27 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 105-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxins
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adverse effects* Animals DNA / metabolism Dietary Proteins / administration & dosage* Drug-Induced Liver Injury* Liver / metabolism, pathology Liver Diseases / metabolism, pathology Macaca mulatta |
| Grant Support | |
ID/Acronym/Agency:
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01-617-4//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Dietary Proteins; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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