Document Detail


Aflatoxin B1-induced injury in monkeys.
MedLine Citation:
PMID:  6893915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Short-term effects of small doses of aflatoxin (0.05 mg/kg of body weight twice a week) were studied in rhesus monkeys fed low-protein and high-protein diets. Animals on high- and low-protein diets without aflatoxin administration served as controls. There was no difference in weight gain, hemogram, serum protein levels, and liver function test results between aflatoxin-treated and control animals. However, morphological alterations in hepatocytes in the form of mild degenerative changes, focal areas of necrosis, and increased regenerative activity were seen in the aflatoxin-treated monkeys. Data on cell cycle analysis done by DNA content estimation through microfluorimetry on DNA-fluorescent, acriflavin-stained liver imprints revealed larger number of cells in the S and Gi2 phases in animals given aflatoxin. However, the changes in cell cycle, as well as in morphology, were more marked in the aflatoxin-treated, low-protein-diet group.
Authors:
V Singhal; M Mathur; V Ramalingaswami; M G Deo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  105     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aflatoxins / adverse effects*
Animals
DNA / metabolism
Dietary Proteins / administration & dosage*
Drug-Induced Liver Injury*
Liver / metabolism,  pathology
Liver Diseases / metabolism,  pathology
Macaca mulatta
Grant Support
ID/Acronym/Agency:
01-617-4//PHS HHS
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Dietary Proteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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