| Aflatoxin B1 alters protein phosphorylation in rat livers. | |
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MedLine Citation:
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PMID: 3925944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was conducted on the effect of aflatoxin B1 on protein phosphorylation in rat livers by incubation of soluble and insoluble cell fractions with [gamma 32P] ATP. SDS-polyacrylamide gel electrophoresis indicated that a total of eight rat liver phosphoproteins were affected during a feeding period of 36 weeks on a carcinogenic aflatoxin B1-containing diet compared to the phosphoprotein patterns obtained from the livers of rats on a normal noncarcinogenic diet. The appearance of only two of these phosphoproteins were cAMP dependent. DEAE-cellulose chromatography employed to separate the different histone kinase activities in soluble rat liver cell fractions, showed that the specific activity of histone kinase I activity was increased but its total activity decreased while the histone kinase II activity stayed unchanged for rats submitted to the aflatoxin B1-containing diet compared to those on the normal noncarcinogenic diet. |
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Authors:
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J Viviers; J C Schabort |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 129 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-07-29 Completed Date: 1985-07-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 342-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxin B1 Aflatoxins / toxicity* Animals Liver / drug effects*, metabolism Male Phosphoproteins / metabolism* Phosphorylation Protein Kinases / metabolism Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Phosphoproteins; 1162-65-8/Aflatoxin B1; EC 2.7.-/Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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