Document Detail

Aflaquinolones A-G: secondary metabolites from marine and fungicolous isolates of Aspergillus spp.
MedLine Citation:
PMID:  22295903     Owner:  NLM     Status:  MEDLINE    
Seven new compounds (aflaquinolones A-G; 1-7) containing dihydroquinolin-2-one and terpenoid units have been isolated from two different fungal sources. Two of these metabolites (1 and 2) were obtained from a Hawaiian fungicolous isolate of Aspergillus sp. (section Flavipedes; MYC-2048 = NRRL 58570), while the others were obtained from a marine Aspergillus isolate (SF-5044) collected in Korea. The structures of these compounds were determined mainly by analysis of NMR and MS data. Relative and absolute configurations were assigned on the basis of NOESY data and (1)H NMR J-values, comparison of calculated and experimental ECD spectra, and analysis of a Mosher's ester derivative of 2. Several known compounds, including alantrypinone, aspochalasins I and J, methyl 3,4,5-trimethoxy-2((2-((3-pyridinylcarbonyl)amino)benzoyl)amino)benzoate, and trans-dehydrocurvularin were also encountered in the extract of the Hawaiian isolate.
Scott A Neff; Sang Un Lee; Yukihiro Asami; Jong Seog Ahn; Hyuncheol Oh; Jonas Baltrusaitis; James B Gloer; Donald T Wicklow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-02-01
Journal Detail:
Title:  Journal of natural products     Volume:  75     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-23     Completed Date:  2012-05-22     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-72     Citation Subset:  IM    
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States.
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MeSH Terms
Aspergillus / chemistry*
Democratic People's Republic of Korea
HL-60 Cells
Marine Biology
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Quinolones / chemistry,  isolation & purification*
Staphylococcus aureus
Grant Support
S10 RR023384/RR/NCRR NIH HHS; S10 RR023384-01/RR/NCRR NIH HHS; S10 RR025500/RR/NCRR NIH HHS; S10 RR025500-01/RR/NCRR NIH HHS
Reg. No./Substance:

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