Document Detail

Afferent vagal fibres with an expiratory discharge in the rabbit.
MedLine Citation:
PMID:  5500999     Owner:  NLM     Status:  MEDLINE    
1. An investigation was undertaken in the spontaneously breathing, anaesthetized rabbit to observe the response of vagal sensory endings to inflation and deflation stimuli which were sufficient to produce Hering-Breuer reflexes.2. When artificial changes in lung volume were produced by applying step changes in intratracheal pressure, activity in pulmonary stretch receptors increased with inflation and decreased with deflation.3. A small number of vagal afferent fibres were encountered which exhibited a discharge with a respiratory modulation consisting of an increase in activity during the phase of expiration. This pattern of discharge was accentuated when the animal was artificially ventilated with the chest either open or closed.4. These expiratory receptors were stimulated by step changes in intratracheal pressure of -5 and +15 mm Hg to produce a high frequency, slowly adapting discharge which persisted for the 10 sec period of the pressure application. The endings were localized in the extrapulmonary bronchi and lung parenchyma and the afferent fibres were myelinated with conduction velocities of 10.6-29.5 m/sec.5. The pronounced effect of deflation stimuli on the endings indicates that they probably act as one of the afferent mechanisms in the Hering-Breuer deflation reflex.
J C Luck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  211     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1970 Nov 
Date Detail:
Created Date:  1971-04-06     Completed Date:  1971-04-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  63-71     Citation Subset:  IM    
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MeSH Terms
Bronchi / innervation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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