Document Detail

Affective syndromes, psychotic features, and prognosis. I. Depression.
MedLine Citation:
PMID:  2360858     Owner:  NLM     Status:  MEDLINE    
Prognosis is an important issue among patients who have psychotic features and a depressive syndrome; some have outcomes that suggest diagnostic revisions to schizophrenia, and this has far-reaching implications for treatment. To explore this issue, we used biannual evaluations to follow up 103 such individuals for 5 years. Patients with Research Diagnostic Criteria schizoaffective disorder experienced substantially more morbidity of various sorts than did patients with Research Diagnostic Criteria psychotic major depression. Within the group with schizoaffective disorder, patients with the chronic subtype experienced more morbidity than did those with nonchronic schizoaffective disorder; the mainly affective--mainly schizophrenic distinction had less prognostic significance. Factors that predicted sustained delusions at the end of follow-up were exclusively historical and suggested a poor-outcome prototype patient who is single, was socially impaired as an adolescent, and has a history of schizophrenialike psychotic features temporarily dissociated from affective symptoms.
W Coryell; M Keller; P Lavori; J Endicott
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  47     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-01     Completed Date:  1990-08-01     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  651-7     Citation Subset:  AIM; IM    
National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, Bethesda, Md.
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MeSH Terms
Age Factors
Bipolar Disorder / diagnosis,  psychology
Depressive Disorder / diagnosis*,  psychology
Educational Status
Follow-Up Studies
Psychiatric Status Rating Scales
Psychotic Disorders / diagnosis*,  psychology
Risk Factors
Grant Support

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