| Affective reactivity in heroin-dependent patients with antisocial personality disorder. | |
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MedLine Citation:
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PMID: 21075454 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The antisocial personality disorder (ASPD), one of the most common co-morbid psychiatric disorders in heroin-dependent patients, is associated with a lack of affective modulation. The present study aimed to compare the affect-modulated startle responses of opioid-maintained heroin-dependent patients with and without ASPD relative to those of healthy controls. Sixty participants (20 heroin-dependent patients with ASPD, 20 heroin-dependent patients without ASPD, 20 healthy controls) were investigated in an affect-modulated startle experiment. Participants viewed neutral, pleasant, unpleasant, and drug-related stimuli while eye-blink responses to randomly delivered startling noises were recorded continuously. Both groups of heroin-dependent patients exhibited significantly smaller startle responses (raw values) than healthy controls. However, they showed a normal affective modulation: higher startle responses to unpleasant, lower startle responses to pleasant stimuli and no difference to drug-related stimuli compared to neutral stimuli. These findings indicate a normally modulated affective reactivity in heroin-dependent patients with ASPD. |
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Authors:
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Marc Walter; Bigna Degen; Constanze Treugut; Jürgen Albrich; Monika Oppel; André Schulz; Hartmut Schächinger; Kenneth M Dürsteler-Macfarland; Gerhard A Wiesbeck |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-11-12 |
Journal Detail:
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Title: Psychiatry research Volume: - ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
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Psychiatric Hospital, Division of Substance Use Disorders, University of Basel, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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