Document Detail

Affect of seizures during gestation on pregnancy outcomes in women with epilepsy.
MedLine Citation:
PMID:  19667219     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess whether seizures in women with epilepsy during pregnancy contribute to adverse pregnancy outcomes. DESIGN: A retrospective cross-sectional study. SETTING: Taiwan. Patients This study linked 2 nationwide population-based data sets: Taiwan's birth certificate registry and the Taiwan National Health Insurance Research Data set. A total of 1016 women with epilepsy were selected who had single births from 2001 to 2003 and who had been diagnosed with epilepsy within 2 years prior to their index delivery, together with 8128 matched women without chronic disease as a comparison cohort. Women with epilepsy were further stratified into 2 groups for analysis: women who did and did not have seizures during pregnancy. MAIN OUTCOME MEASURES: Low-birth-weight infants, preterm delivery, and infants who are small for gestational age (SGA). RESULTS: Compared with women without epilepsy, epileptic seizures during pregnancy were independently associated with a 1.36-fold (95% confidence interval [CI], 1.01-1.88), 1.63-fold (95% CI, 1.21-2.19), and 1.37-fold (95% CI, 1.09-1.70) increased risk of low-birth-weight infants, preterm delivery, and SGA, respectively, after adjusting for family income and parental and infant characteristics. Further, the risk of SGA increased significantly (odds ratio, 1.34; 95% CI, 1.01-1.84) for women with seizures during pregnancy compared with women with epilepsy who did not have seizures during pregnancy. CONCLUSION: We suggest preventing seizures during pregnancy as an essential step to reduce risk of adverse pregnancy outcomes.
Yi-Hua Chen; Hung-Yi Chiou; Herng-Ching Lin; Hsiu-Li Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  66     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-08-20     Revised Date:  2010-06-30    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  979-84     Citation Subset:  AIM; IM    
School of Public Health, Taipei Medical University, Taipei, Taiwan.
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MeSH Terms
Case-Control Studies
Cross-Sectional Studies
Educational Status
Epilepsy / epidemiology*
Infant, Low Birth Weight*
Infant, Newborn
Infant, Small for Gestational Age*
Obstetric Labor, Premature / epidemiology*
Paternal Age
Pregnancy Complications / epidemiology*
Pregnancy Outcome / epidemiology*
Risk Factors
Socioeconomic Factors
Young Adult
Comment In:
Epilepsy Curr. 2010 Mar;10(2):40-1   [PMID:  20231921 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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