Document Detail


Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women.
MedLine Citation:
PMID:  20926522     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Iron deficiency anemia (IDA) affects many young women in sub-Saharan Africa. Its etiology is multifactorial, but the major cause is low dietary iron bioavailability exacerbated by parasitic infections such as malaria.
OBJECTIVE: We investigated whether asymptomatic Plasmodium falciparum parasitemia in Beninese women would impair absorption of dietary iron or utilization of circulating iron.
DESIGN: Iron absorption and utilization from an iron-fortified sorghum-based meal were estimated by using oral and intravenous isotope labels in 23 afebrile women with a positive malaria smear (asexual P. falciparum parasitemia; > 500 parasites/μL blood). The women were studied while infected, treated, and then restudied 10 d after treatment. Iron status, hepcidin, and inflammation indexes were measured before and after treatment.
RESULTS: Treatment reduced low-grade inflammation, as reflected by decreases in serum ferritin, C-reactive protein, interleukin-6, interleukin-8, and interleukin-10 (P < 0.05); this was accompanied by a reduction in median serum hepcidin of ≈ 50%, from 2.7 to 1.4 nmol/L (P < 0.005). Treatment decreased serum erythropoietin and growth differentiation factor 15 (P < 0.05). Clearance of parasitemia increased geometric mean dietary iron absorption (from 10.2% to 17.6%; P = 0.008) but did not affect systemic iron utilization (85.0% compared with 83.1%; NS).
CONCLUSIONS: Dietary iron absorption is reduced by ≈ 40% in asymptomatic P. falciparum parasitemia, likely because of low-grade inflammation and its modulation of circulating hepcidin. Because asymptomatic parasitemia has a protracted course and is very common in malarial areas, this effect may contribute to IDA and blunt the efficacy of iron supplementation and fortification programs. This trial was registered at clinicaltrials.gov as NCT01108939.
Authors:
Colin I Cercamondi; Ines M Egli; Ella Ahouandjinou; Romain Dossa; Christophe Zeder; Lamidhi Salami; Harold Tjalsma; Erwin Wiegerinck; Toshihiko Tanno; Richard F Hurrell; Joseph Hounhouigan; Michael B Zimmermann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-06
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-23     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1385-92     Citation Subset:  AIM; IM    
Affiliation:
Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zürich, Zurich, Switzerland. colin.cercamondi@ilw.agrl.ethz.ch
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01108939
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia, Iron-Deficiency / drug therapy,  etiology,  metabolism*
Antimicrobial Cationic Peptides / blood
Benin
Erythropoietin / blood
Female
Ferritins / blood
Food, Fortified
Growth Differentiation Factor 15 / blood
Humans
Inflammation / drug therapy,  metabolism,  parasitology
Inflammation Mediators / blood
Intestinal Absorption
Iron, Dietary / metabolism,  pharmacokinetics*
Isotope Labeling
Malaria, Falciparum / complications,  drug therapy,  metabolism*
Parasitemia / drug therapy,  metabolism*
Plasmodium falciparum*
Sorghum
Young Adult
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Growth Differentiation Factor 15; 0/Inflammation Mediators; 0/Iron, Dietary; 0/hepcidin; 11096-26-7/Erythropoietin; 9007-73-2/Ferritins
Comments/Corrections
Comment In:
Am J Clin Nutr. 2010 Dec;92(6):1285-6   [PMID:  21068352 ]
Am J Clin Nutr. 2010 Dec;92(6):1283-4   [PMID:  21068349 ]

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