| Aetiology and physiopathology of preeclampsia and related forms. | |
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MedLine Citation:
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PMID: 20954461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and oedema, resolves on placental delivery. Its pathogenesis is thought to be associated to a hypoxic placenta. Placental hypoxia is responsible for the maternal vascular dysfunction via the increased placental release of anti-angiogenic factors such as soluble flt1 and endoglin. These soluble receptors bind VEGF, PLGF and TGFbeta1 and 3 in the maternal circulation, causing endothelial dysfunction in many maternal tissues. Despite these recent and important new molecular findings, it is important to consider that normal pregnancy is also characterized by systemic inflammation, oxidative stress and alterations in levels of angiogenic factors and vascular reactivity. Both the placenta and maternal vasculatures are major sources of reactive oxygen and nitrogen species which can produce powerful pro-oxidants that covalently modify proteins and alter vascular function in preeclampsia. Finally, the recent demonstration of activating auto-antibodies to the Angiotensin 1 receptor that experimentally play a major pathogenic role in preeclampsia further indicates the pleiotropism of aetiologies of this condition. |
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Authors:
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S Lorquet; C Pequeux; C Munaut; J M Foidart |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Acta clinica Belgica Volume: 65 ISSN: 0001-5512 ISO Abbreviation: Acta Clin Belg Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370306 Medline TA: Acta Clin Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 237-41 Citation Subset: IM |
Affiliation:
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Department Universitaire de Gynécologie Obstétrique, Hôpital de La Citadelle, Liège, Belgique. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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complications,
metabolism,
physiopathology Antigens, CD / metabolism Female Humans Oxidative Stress Peptide Hydrolases / metabolism Placenta / blood supply, metabolism, physiopathology Pre-Eclampsia / etiology*, metabolism, physiopathology* Pregnancy Pregnancy Proteins / metabolism Receptors, Cell Surface / metabolism Renin-Angiotensin System / physiology Risk Factors Vascular Endothelial Growth Factor A / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/ENG protein, human; 0/Pregnancy Proteins; 0/Receptors, Cell Surface; 0/Vascular Endothelial Growth Factor A; EC 3.4.-/Peptide Hydrolases |
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