Document Detail

Aetiology of oesophageal cancer: some operative factors.
MedLine Citation:
PMID:  1463984     Owner:  NLM     Status:  MEDLINE    
Of the thousands of chemicals tested, the only compounds found to be potent carcinogens for the oesophagus are the N-nitrosamines. Many of these compounds are readily formed from common precursors in the environment (eg example in food during its storage or preparation) and also in vivo in the human stomach. Exposure is therefore likely to be ubiquitous. Although man may be exposed to other oesophageal carcinogens these have yet to be chemically identified, and at present nitrosamines are the sole contenders for the role of initiators of oesophageal cancer in man. Evidence suggests strongly that oesophageal cancer is initiated world-wide by nitrosamines, and promoted by secondary factors, the nature of which varies with the population concerned, notably alcohol in Europe and the USA, dietary deficiencies in China and Iran, mycotoxins in South Africa. When several risk factors coincide in one locality, the result can be a very high incidence of oesophageal cancer, with no one major cause.
V M Craddock
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)     Volume:  1     ISSN:  0959-8278     ISO Abbreviation:  Eur. J. Cancer Prev.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1993-01-15     Completed Date:  1993-01-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9300837     Medline TA:  Eur J Cancer Prev     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  89-103     Citation Subset:  IM    
MRC Toxicology Unit, Carshalton, Surrey, UK.
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MeSH Terms
Esophageal Neoplasms / etiology*
Risk Factors
Reg. No./Substance:

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