Document Detail

Aerosolized prostacyclins.
MedLine Citation:
PMID:  15165299     Owner:  NLM     Status:  MEDLINE    
Two prostacyclins (prostaglandin E(1) and prostaglandin I(2)) are potent vasodilators. Aerosolized prostacyclins reduce pulmonary artery pressure, improve right heart function, and increase arterial oxygenation by improving ventilation/perfusion matching. This report describes aerosolized prostacyclins and compares them to inhaled nitric oxide. I review the types of inhalable prostacyclins and their indications, evidence of efficacy, delivery, and adverse effects.
Mark Siobal
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Respiratory care     Volume:  49     ISSN:  0020-1324     ISO Abbreviation:  Respir Care     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  640-52     Citation Subset:  IM    
Respiratory Care Services, San Francisco General Hospital, NH GA-2, 1001 Potrero Avenue, San Francisco, CA 94110, USA.
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MeSH Terms
Administration, Inhalation
Alprostadil / administration & dosage
Dose-Response Relationship, Drug
Epoprostenol / administration & dosage
Equipment Design
Hypertension, Pulmonary / drug therapy
Iloprost / administration & dosage
Nebulizers and Vaporizers
Nitric Oxide / administration & dosage
Prostaglandins I / administration & dosage*,  adverse effects
Respiratory Distress Syndrome, Adult / drug therapy
Respiratory Therapy / instrumentation,  methods*
Treatment Outcome
Vasodilator Agents / administration & dosage*,  adverse effects
Ventricular Dysfunction, Right / drug therapy
Reg. No./Substance:
0/Aerosols; 0/Prostaglandins I; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 35121-78-9/Epoprostenol; 745-65-3/Alprostadil; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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