Document Detail

Aerobic training restores arterial baroreflex sensitivity in older adults with type 2 diabetes, hypertension, and hypercholesterolemia.
MedLine Citation:
PMID:  20606518     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Lowered baroreflex sensitivity (BRS) predicts mortality and occurs with increasing age and diabetes. We examined whether aerobic exercise could restore arterial BRS in adults at high cardiovascular risk (diabetes, geriatric age group, hypercholesterolemia, and hypertension).
DESIGN: Randomized, controlled, single-blind study.
SETTING: VITALiTY (Vancouver Initiative to Add Life to Years) Research Laboratory.
PARTICIPANTS: Thirty-nine older adults (mean age, 71.5 +/- 0.7 years) with diet-controlled or oral hypoglycemic-controlled type 2 diabetes, hypertension, and hypercholesterolemia.
INTERVENTIONS: Subjects were recruited to each of 2 groups: an aerobic group (3 months of vigorous aerobic exercise as defined by 80% to 85% of maximal heart rate), and a nonaerobic (no aerobic exercise) group. Exercise sessions were supervised by a certified exercise trainer 3 times per week.
MAIN OUTCOME MEASURES: : Baroreflex function was assessed using the spontaneous baroreflex method. Main outcome measures included BRS, BRS(up), BRS(down), and [latin capital V with dot above]o(2)max.
RESULTS: The aerobic group demonstrated an increase in BRS that was not demonstrated in the nonaerobic group (+60.9 +/- 23.5 vs +2.2 +/- 7.9%; P = 0.010).
CONCLUSIONS: Our findings indicate that a relatively short aerobic exercise intervention can reverse functional impairments of the arterial baroreflex function in older adults at high cardiovascular risk.
Kenneth M Madden; Chris Lockhart; Tiffany F Potter; Darcye Cuff
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine     Volume:  20     ISSN:  1536-3724     ISO Abbreviation:  Clin J Sport Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2010-10-29     Revised Date:  2014-03-03    
Medline Journal Info:
Nlm Unique ID:  9103300     Medline TA:  Clin J Sport Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  312-7     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Baroreflex / physiology*
Blood Pressure / physiology
Diabetes Mellitus, Type 2 / physiopathology*
Exercise / physiology*
Hypercholesterolemia / physiopathology*
Hypertension / physiopathology*
Oxygen Consumption / physiology
Single-Blind Method
Grant Support
77789-1//Canadian Institutes of Health Research; 77789-2//Canadian Institutes of Health Research; //Canadian Institutes of Health Research

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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