| Aerobic training restores arterial baroreflex sensitivity in older adults with type 2 diabetes, hypertension, and hypercholesterolemia. | |
| | |
MedLine Citation:
|
PMID: 20606518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Lowered baroreflex sensitivity (BRS) predicts mortality and occurs with increasing age and diabetes. We examined whether aerobic exercise could restore arterial BRS in adults at high cardiovascular risk (diabetes, geriatric age group, hypercholesterolemia, and hypertension). DESIGN: Randomized, controlled, single-blind study. SETTING: VITALiTY (Vancouver Initiative to Add Life to Years) Research Laboratory. PARTICIPANTS: Thirty-nine older adults (mean age, 71.5 +/- 0.7 years) with diet-controlled or oral hypoglycemic-controlled type 2 diabetes, hypertension, and hypercholesterolemia. INTERVENTIONS: Subjects were recruited to each of 2 groups: an aerobic group (3 months of vigorous aerobic exercise as defined by 80% to 85% of maximal heart rate), and a nonaerobic (no aerobic exercise) group. Exercise sessions were supervised by a certified exercise trainer 3 times per week. MAIN OUTCOME MEASURES:: Baroreflex function was assessed using the spontaneous baroreflex method. Main outcome measures included BRS, BRS(up), BRS(down), and [latin capital V with dot above]o(2)max. RESULTS: The aerobic group demonstrated an increase in BRS that was not demonstrated in the nonaerobic group (+60.9 +/- 23.5 vs +2.2 +/- 7.9%; P = 0.010). CONCLUSIONS: Our findings indicate that a relatively short aerobic exercise intervention can reverse functional impairments of the arterial baroreflex function in older adults at high cardiovascular risk. |
| | |
Authors:
|
Kenneth M Madden; Chris Lockhart; Tiffany F Potter; Darcye Cuff |
Related Documents
:
|
19494728 - Improvement in aerobic capacity after an exercise program in sporadic inclusion body my... 21277508 - The environment, the airway, and the athlete. 20605858 - Graduated exercise training and progressive resistance training in adolescents with chr... 9830838 - Affective responses of physically active and sedentary individuals during and after mod... 10331398 - Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humans. 21912268 - A combined aerobic and resistance exercise program improves physical functional perform... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine Volume: 20 ISSN: 1536-3724 ISO Abbreviation: Clin J Sport Med Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-07 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9103300 Medline TA: Clin J Sport Med Country: United States |
Other Details:
|
Languages: eng Pagination: 312-7 Citation Subset: IM |
Affiliation:
|
VITALiTY (Vancouver Initiative to Add Life to Years) Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. kmmadden@interchange.ubc.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Baroreflex / physiology* Blood Pressure / physiology Diabetes Mellitus, Type 2 / physiopathology* Exercise / physiology* Female Humans Hypercholesterolemia / physiopathology* Hypertension / physiopathology* Male Oxygen Consumption / physiology Single-Blind Method |
| Grant Support | |
ID/Acronym/Agency:
|
//Canadian Institutes of Health Research |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxidative stress and inflammatory parameters after an ironman race.
Next Document: Youth marathon runners and race day medical risk over 26 years.