Document Detail

Aerobic training reduces systemic oxidative stress in young women with elevated levels of F2-isoprostanes.
MedLine Citation:
PMID:  23178737     Owner:  NLM     Status:  MEDLINE    
The purpose of this trial was to determine whether exercise without weight loss would reduce F2-isoprostanes in previously sedentary young women. Participants (N=319) were randomized to four months of 150min/week aerobic exercise or a control group. Plasma free F2-isoprostanes were measured by gas chromatography-mass spectrometry. Other assessments included fitness and % body fat. Intervention groups were compared with stratification by quartiles of baseline plasma F2-isoprostane. This stratified comparison was linearly adjusted for baseline plasma F2-isoprostane and we also used baseline plasma F2-isoprostane as a propensity score to balance the intervention. Training resulted in significant improvements in aerobic fitness (0.88 METs) and body fat percent (1%) in exercisers compared to controls (p<0.001). The exercise group had significantly higher mean baseline plasma F2-isoprostanes (79.1 vs 67.9pg/mL) than the control group in the highest quartile of baseline plasma F2-isoprostanes. Within this highest quartile, exercise led to a greater decline in plasma F2-isoprostanes (-20.2±2.5pg/mL) than control (-7.4±2.5pg/mL); with adjustment for baseline plasma F2-isoprostanes and in the balanced groups, this difference was reduced but remained significant. Four months of exercise training resulted in significant reductions of systemic oxidative stress only among previously sedentary young women who were in the highest quartile of plasma F2-isoprostanes at baseline (≥57pg/mL). Our findings indicate that the benefits of aerobic exercise in reducing systemic oxidative stress may be limited to those who present higher baseline levels of plasma F2-isoprostanes.
Andrea Y Arikawa; William Thomas; Myron Gross; Alma Smith; William R Phipps; Mindy S Kurzer; Kathryn H Schmitz
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-11-22
Journal Detail:
Title:  Contemporary clinical trials     Volume:  34     ISSN:  1559-2030     ISO Abbreviation:  Contemp Clin Trials     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-19     Revised Date:  2014-06-06    
Medline Journal Info:
Nlm Unique ID:  101242342     Medline TA:  Contemp Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  212-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Biological Markers / blood
Body Composition / physiology
Exercise / physiology*
Exercise Therapy / methods*
F2-Isoprostanes / blood*
Gas Chromatography-Mass Spectrometry
Oxidative Stress / physiology*
Physical Fitness
Reactive Oxygen Species
Sedentary Lifestyle
Treatment Outcome
Young Adult
Grant Support
U54 CA116849/CA/NCI NIH HHS; U54 CA155850/CA/NCI NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/F2-Isoprostanes; 0/Reactive Oxygen Species

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