Document Detail


Aerobic performance and antioxidant protection in runners.
MedLine Citation:
PMID:  19685417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reactive oxygen species (ROS) production is known to increase as a result of muscular contractile activity and this phenomenon may perturb the fine-controlled cellular redox homeostasis within cells and tissues. We studied the possible correlations between individual aerobic performance-related factors and the oxidative stress markers profile in the serum of thirty-five endurance male runners that experienced a modified Bruce-based maximal graded exercise test. Our investigation assessed the systemic levels of malondialdehyde (MDA), protein carbonyl content (PCC) and total antioxidant status (TAS). We found that redox-related parameters and aerobic performance indicators were correlated. Indeed, significant negative associations between TAS and PCC (r-value -0.7, p<0.001) and between TAS and total protein content (r-value -0.4, p=0.005) were observed. A significant positive association between total protein and PCC (r-value 0.4, p=0.012) was also revealed. Only a trend of negative correlation between serum total protein and anaerobic threshold (r-value -0.3, p=0.07) was found. Interestingly, different responses in MDA levels were elicited by the ergometric test as a function of the individual anaerobic threshold. High aerobic capacities may be promising anthropometric factors indicative of adapted biochemical environments featuring enhanced protection against the oxidative challenge elicited by both regular endurance training and single intense exercise bouts.
Authors:
S Falone; A Mirabilio; A Passerini; P Izzicupo; M Cacchio; S Gallina; A Di Baldassarre; A D Baldassarre; F Amicarelli
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Publication Detail:
Type:  Journal Article     Date:  2009-08-14
Journal Detail:
Title:  International journal of sports medicine     Volume:  30     ISSN:  1439-3964     ISO Abbreviation:  Int J Sports Med     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-01-25     Revised Date:  2011-01-06    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  782-8     Citation Subset:  IM    
Copyright Information:
(c) Georg Thieme Verlag KG Stuttgart . New York.
Affiliation:
University G. d'Annunzio, Department of Biomedical Sciences, Chieti, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anaerobic Threshold / physiology
Antioxidants / metabolism*
Blood Proteins / metabolism
Ergometry
Exercise Test
Humans
Male
Malondialdehyde / metabolism
Middle Aged
Oxidation-Reduction
Oxidative Stress / physiology*
Protein Carbonylation / physiology
Reactive Oxygen Species / metabolism*
Running / physiology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Blood Proteins; 0/Reactive Oxygen Species; 542-78-9/Malondialdehyde
Comments/Corrections
Erratum In:
Int J Sports Med. 2010 Mar;31(3):219
Note: Baldassarre, A D [corrected to Baldassarre, A Di]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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