| Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. | |
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MedLine Citation:
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PMID: 18606913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Individuals with the metabolic syndrome are 3 times more likely to die of heart disease than healthy counterparts. Exercise training reduces several of the symptoms of the syndrome, but the exercise intensity that yields the maximal beneficial adaptations is in dispute. We compared moderate and high exercise intensity with regard to variables associated with cardiovascular function and prognosis in patients with the metabolic syndrome. METHODS AND RESULTS: Thirty-two metabolic syndrome patients (age, 52.3+/-3.7 years; maximal oxygen uptake [o(2)max], 34 mL x kg(-1) x min(-1)) were randomized to equal volumes of either moderate continuous moderate exercise (CME; 70% of highest measured heart rate [Hfmax]) or aerobic interval training (AIT; 90% of Hfmax) 3 times a week for 16 weeks or to a control group. o(2)max increased more after AIT than CME (35% versus 16%; P<0.01) and was associated with removal of more risk factors that constitute the metabolic syndrome (number of factors: AIT, 5.9 before versus 4.0 after; P<0.01; CME, 5.7 before versus 5.0 after; group difference, P<0.05). AIT was superior to CME in enhancing endothelial function (9% versus 5%; P<0.001), insulin signaling in fat and skeletal muscle, skeletal muscle biogenesis, and excitation-contraction coupling and in reducing blood glucose and lipogenesis in adipose tissue. The 2 exercise programs were equally effective at lowering mean arterial blood pressure and reducing body weight (-2.3 and -3.6 kg in AIT and CME, respectively) and fat. CONCLUSIONS: Exercise intensity was an important factor for improving aerobic capacity and reversing the risk factors of the metabolic syndrome. These findings may have important implications for exercise training in rehabilitation programs and future studies. |
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Authors:
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Arnt Erik Tjønna; Sang Jun Lee; Øivind Rognmo; Tomas O Stølen; Anja Bye; Per Magnus Haram; Jan Pål Loennechen; Qusai Y Al-Share; Eirik Skogvoll; Stig A Slørdahl; Ole J Kemi; Sonia M Najjar; Ulrik Wisløff |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-07-07 |
Journal Detail:
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Title: Circulation Volume: 118 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-22 Completed Date: 2008-08-13 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 346-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00218998 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Weight Cardiovascular Diseases / prevention & control* Exercise Therapy / methods*, standards Female Heart Rate Humans Male Metabolic Syndrome X / complications, physiopathology, therapy* Metabolism Middle Aged Oxygen Consumption Pilot Projects |
| Grant Support | |
ID/Acronym/Agency:
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DK 54254/DK/NIDDK NIH HHS; R01 DK054254-01A2/DK/NIDDK NIH HHS; R01 DK054254-05A2/DK/NIDDK NIH HHS |
| Comments/Corrections | |
Comment In:
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Circulation. 2009 Mar 3;119(8):e225; author reply e226
[PMID:
19255350
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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