Document Detail

Aerobic fitness, fatigue, and physical disability in systemic lupus erythematosus.
MedLine Citation:
PMID:  11908559     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure aerobic fitness, muscle strength, fatigue, and physical disability in patients with systemic lupus erythematosus (SLE). METHODS: Ninety-three patients with SLE and 41 sedentary controls were recruited into the study. Aerobic fitness was assessed by monitoring peak and submaximal oxygen uptake, heart rate, duration of exercise, and perceived exertion during a treadmill-walking test. Strength was measured using voluntary isometric quadriceps contraction. Symptomatic measures included physical and mental fatigue, mood, sleep, and functional incapacity. RESULTS: Compared to sedentary controls patients with SLE had significantly reduced levels of aerobic fitness (mean VO2peak SLE patients, 23.2 ml/kg/min vs controls, 29.6 ml/kg/min; p < 0.001) and reduced exercise capacity (mean exercise duration SLE patients, 10.4 min vs controls, 13.1 min; p < 0.001). The SLE patients also had reduced muscle strength (mean maximum voluntary quadriceps contraction SLE patients, 298 N vs controls, 376 N; p = 0.003). Resting lung function was also significantly worse in the SLE patients (mean FEV, SLE patients, 2.6 l vs controls, 2.9 l; p = 0.002). Fatigue (p < 0.001), depressed mood (p < 0.001), poor sleep quality (p < 0.001), and functional incapacity (p < 0.001) were all significantly greater in the SLE patients. Linear regression models suggested that physical disability correlated with aerobic fitness (p < 0.001), fatigue (p = 0.005), body mass index (p = 0.01), and depression (p = 0.05) and that fatigue correlated with depression (p < 0.001). CONCLUSION: Patients with SLE were less fit with reduced exercise capacity, reduced muscle strength, more fatigue, and greater disability compared to sedentary controls. Treatments developed to manage depression and improve aerobic fitness should be considered in the overall treatment of fatigue and disability in SLE.
Colin Tench; David Bentley; Veronica Vleck; Ian McCurdie; Peter White; David D'Cruz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  29     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-22     Completed Date:  2002-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  474-81     Citation Subset:  IM    
Bone and Joint Research Unit, St. Bartholomew's, London, UK.
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MeSH Terms
Disability Evaluation
Exercise Test
Exercise Therapy*
Fatigue / etiology*,  therapy*
Heart Rate
Lupus Erythematosus, Systemic / complications*,  rehabilitation*
Oxygen Consumption
Physical Fitness
Prospective Studies
Regression Analysis
Respiratory Function Tests

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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