Document Detail

Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension.
MedLine Citation:
PMID:  22994554     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Regular physical activity is an effective non-pharmacological therapy for prevention and control of hypertension. We investigated the effects of aerobic exercise training in vascular remodelling and in the mechanical and functional alterations of coronary and small mesenteric arteries from spontaneously hypertensive rats (SHR).
EXPERIMENTAL APPROACH: Normotensive Wistar Kyoto (WKY), SHR and SHR trained on a treadmill for 12 weeks were used to evaluate vascular structural, mechanical and functional properties.
KEY RESULTS: Exercise did not affect lumen diameter, wall thickness and wall/lumen ratio but reduced vascular stiffness of coronary and mesenteric arteries from SHR. Exercise also reduced collagen deposition and normalized altered internal elastic lamina organization and expression of MMP-9 in mesenteric arteries from SHR. Exercise did not affect contractile responses of coronary arteries but improved the endothelium-dependent relaxation in SHR. In mesenteric arteries, training normalized the increased contractile responses induced by U46619 and by high concentrations of acetylcholine. In vessels from SHR, exercise normalized the effects of the NADPH oxidase inhibitor apocynin and the NOS inhibitor l-NAME in vasodilator or vasoconstrictor responses, normalized the increased O(2) (-) production and the reduced Cu/Zn superoxide dismutase expression and increased NO production.
CONCLUSIONS AND IMPLICATIONS: Exercise training of SHR improves endothelial function and vascular stiffness in coronary and small mesenteric arteries. This might be related to the concomitant decrease of oxidative stress and increase of NO bioavailability. Such effects demonstrate the beneficial effects of exercise on the vascular system and could contribute to a reduction in blood pressure.
Fernanda R Roque; Ana M Briones; Ana B García-Redondo; María Galán; Sonia Martínez-Revelles; Maria S Avendaño; Victoria Cachofeiro; Tiago Fernandes; Dalton V Vassallo; Edilamar M Oliveira; Mercedes Salaices
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  168     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-07-02     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  686-703     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.
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MeSH Terms
Blood Pressure
Citrate (si)-Synthase / metabolism
Collagen / metabolism
Coronary Vessels / metabolism,  physiopathology*
Heart Rate
Hypertension / physiopathology,  therapy*
Mesenteric Arteries / metabolism,  physiopathology*
Nitric Oxide / metabolism
Nitrites / blood
Oxidative Stress
Physical Conditioning, Animal*
Rats, Inbred SHR
Rats, Inbred WKY
Superoxides / metabolism
Reg. No./Substance:
0/Nitrites; 11062-77-4/Superoxides; 31C4KY9ESH/Nitric Oxide; 9007-34-5/Collagen; EC (si)-Synthase

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