| Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension. | |
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MedLine Citation:
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PMID: 22994554 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Regular physical activity is an effective non-pharmacological therapy for prevention and control of hypertension. We investigated the effects of aerobic exercise training in vascular remodeling and in the mechanical and functional alterations of coronary and small mesenteric arteries from spontaneously hypertensive rats (SHR). EXPERIMENTAL APPROACH: Normotensive Wistar Kyoto (WKY), SHR and SHR-Trained rats (treadmill, 12 weeks) were used to evaluate vascular structural, mechanical and functional properties. KEY RESULTS: Exercise did not affect lumen diameter, wall thickness and wall/lumen ratio, but reduced vascular stiffness of coronary and mesenteric arteries from SHR. Exercise also reduced collagen deposition and normalized altered internal elastic lamina organization and matrix metalloproteinase 9 expression in mesenteric arteries from SHR. Exercise did not affect contractile responses of coronary arteries but improved the endothelium-dependent relaxation in SHR. In mesenteric arteries, training normalized the increased contractile responses induced by U46619 and by high concentrations of acetylcholine. In vessels from SHR, exercise: 1) normalized the effects of the NADPH oxidase inhibitor apocynin and the NOS inhibitor L-NAME in vasodilator or vasoconstrictor responses; 2) normalized the increased O(2) (.-) production and the reduced Cu/Zn superoxide dismutase expression and 3) increased NO production. CONCLUSIONS AND IMPLICATIONS: Exercise training of SHR improves endothelial function and vascular stiffness in coronary and small mesenteric arteries. This might be related with the concomitant decrease of oxidative stress and the increase of NO bioavailability. These events might contribute to reduce blood pressure and provide evidences of the beneficial effects of exercise on the vascular system. |
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Authors:
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Fernanda R Roque; Ana M Briones; Ana B García-Redondo; María Galán; Sonia Martínez-Revelles; Maria S Avendaño; Victoria Cachofeiro; Tiago Fernandes; Dalton V Vassallo; Edilamar M Oliveira; Mercedes Salaices |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-21 |
Journal Detail:
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Title: British journal of pharmacology Volume: - ISSN: 1476-5381 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society. |
Affiliation:
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Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, España; Laboratório de Bioquímica e Biologia Molecular do Exercício, Departamento de Biodinâmica do Movimento do Corpo Humano, Escola de Educação Física e Esporte, Universidade de São Paulo, São Paulo, SP, Brasil. |
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