Document Detail


Aerobic exercise does not compromise muscle hypertrophy response to short-term resistance training.
MedLine Citation:
PMID:  23104700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study tested the hypothesis that chronic aerobic and resistance exercise (AE+RE) would elicit greater muscle hypertrophy than resistance exercise only (RE). Ten men (25 ± 4 yr) performed 5 wk unilateral knee extensor AE+RE. The opposing limb was subjected to RE. AE completed 6 hr prior to RE consisted of ~45 min one-legged cycle ergometry. RE comprised 4 × 7 maximal concentric-eccentric knee extensions. Various indexes of in vivo knee extensor function were measured before and after training. Magnetic resonance imaging (MRI) assessed m. quadricep femoris (QF) cross-sectional area (CSA), volume, and signal intensity (SI). Biopsies obtained from m. vastus lateralis determined fiber CSA, enzyme levels, and gene expression of myostatin, atrogin-1, MuRF-1, PGC-1α, and VEGF. Increases (P < 0.05) in isometric strength and peak power, respectively, were comparable in AE+RE (9 and 29%) and RE (11 and 24%). AE+RE showed greater increase (14%; P < 0.05) in QF volume than RE (8%). Muscle fiber CSA increased 17% after AE+RE (P < 0.05) and 9% after RE (P > 0.05). QF SI increased (12%; P < 0.05) after AE+RE, but not RE. Neither AE+RE nor RE showed altered mRNA levels. Citrate synthase activity increased (P < 0.05) after AE+RE. The results suggest that the increased aerobic capacity shown with AE+RE was accompanied by a more robust increase in muscle size compared with RE. Although this response was not carried over to greater improvement in muscle function, it remains that intense AE can be executed prior to RE without compromising performance outcome.
Authors:
Tommy R Lundberg; Rodrigo Fernandez-Gonzalo; Thomas Gustafsson; Per A Tesch
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-25
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  114     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-07-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-9     Citation Subset:  IM    
Affiliation:
Department of Health Sciences, Mid Sweden University, Östersund, Sweden. tommy.lundberg@miun.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise / physiology*
Gene Expression / genetics
Glycogen / genetics,  metabolism
Heat-Shock Proteins / genetics,  metabolism
Humans
Hypertrophy / physiopathology
Isometric Contraction / genetics,  physiology
Knee Joint / metabolism,  physiology
L-Lactate Dehydrogenase / genetics,  metabolism
Male
Muscle Fibers, Skeletal / metabolism,  pathology*,  physiology*
Muscle Proteins / genetics,  metabolism
Myostatin / genetics,  metabolism
RNA, Messenger / genetics
Resistance Training / methods
SKP Cullin F-Box Protein Ligases / genetics,  metabolism
Transcription Factors / genetics,  metabolism
Ubiquitin-Protein Ligases / genetics,  metabolism
Vascular Endothelial Growth Factor A / genetics,  metabolism
Water / metabolism
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins; 0/Muscle Proteins; 0/Myostatin; 0/PPARGC1A protein, human; 0/RNA, Messenger; 0/Transcription Factors; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 7732-18-5/Water; 9005-79-2/Glycogen; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 6.3.2.19/FBXO32 protein, human; EC 6.3.2.19/SKP Cullin F-Box Protein Ligases; EC 6.3.2.19/TRIM63 protein, human; EC 6.3.2.19/Ubiquitin-Protein Ligases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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