Document Detail


Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke.
MedLine Citation:
PMID:  21700603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has recently been suggested that regular exercise reduces lung function decline and risk of chronic obstructive pulmonary disease (COPD) among active smokers; however, the mechanisms involved in this effect remain poorly understood. The present study evaluated the effects of regular exercise training in an experimental mouse model of chronic cigarette smoke exposure. Male C57BL/6 mice were divided into four groups (control, exercise, smoke and smoke+exercise). For 24 weeks, we measured respiratory mechanics, mean linear intercept, inflammatory cells and reactive oxygen species (ROS) in bronchoalveolar lavage (BAL) fluid, collagen deposition in alveolar walls, and the expression of antioxidant enzymes, matrix metalloproteinase 9, tissue inhibitor of metalloproteinase (TIMP)1, interleukin (IL)-10 and 8-isoprostane in alveolar walls. Exercise attenuated the decrease in pulmonary elastance (p<0.01) and the increase in mean linear intercept (p=0.003) induced by cigarette smoke exposure. Exercise substantially inhibited the increase in ROS in BAL fluid and 8-isoprostane expression in lung tissue induced by cigarette smoke. In addition, exercise significantly inhibited the decreases in IL-10, TIMP1 and CuZn superoxide dismutase induced by exposure to cigarette smoke. Exercise also increased the number of cells expressing glutathione peroxidase. Our results suggest that regular aerobic physical training of moderate intensity attenuates the development of pulmonary disease induced by cigarette smoke exposure.
Authors:
A C Toledo; R M Magalhaes; D C Hizume; R P Vieira; P J C Biselli; H T Moriya; T Mauad; F D T Q S Lopes; M A Martins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-23
Journal Detail:
Title:  The European respiratory journal     Volume:  39     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-02     Completed Date:  2012-05-29     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  254-64     Citation Subset:  IM    
Affiliation:
Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo 455, sala 1210, 01256-903, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism
Bronchoalveolar Lavage Fluid / cytology,  immunology
Dinoprost / analogs & derivatives,  metabolism
Emphysema / etiology,  physiopathology,  prevention & control
Interleukin-10 / metabolism
Macrophages, Alveolar / metabolism
Male
Matrix Metalloproteinase 9 / metabolism
Mice
Mice, Inbred C57BL
Oxidative Stress / physiology*
Physical Conditioning, Animal / physiology*
Pulmonary Alveoli / metabolism,  physiopathology
Pulmonary Disease, Chronic Obstructive* / etiology,  physiopathology,  prevention & control
Reactive Oxygen Species / metabolism
Respiratory Mechanics / physiology*
Tissue Inhibitor of Metalloproteinase-1 / metabolism
Tobacco Smoke Pollution / adverse effects*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/IL10 protein, mouse; 0/Reactive Oxygen Species; 0/Timp1 protein, mouse; 0/Tissue Inhibitor of Metalloproteinase-1; 0/Tobacco Smoke Pollution; 130068-27-8/Interleukin-10; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost; EC 3.4.24.-/Mmp9 protein, mouse; EC 3.4.24.35/Matrix Metalloproteinase 9

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