Document Detail

Aerobic exercise acutely improves insulin- and insulin-like growth factor-1-mediated vasorelaxation in hypertensive rats.
MedLine Citation:
PMID:  20139168     Owner:  NLM     Status:  MEDLINE    
Limited information is available concerning the effects of aerobic exercise on vasorelaxation in hypertension. The aim of this study was to investigate the effects of a single bout of aerobic exercise on insulin- and insulin-like growth factor-1 (IGF-1)-induced vasorelaxation in hypertensive rats. Four-month-old spontaneously hypertensive rats were randomly divided into a sedentary group (SHR) and an exercise group (SHR+Ex) subjected to a single bout of aerobic exercise conducted by treadmill running at 21 m min(1) for 1 h. Age-matched Wistar-Kyoto rats were used as a normotensive control group (WKY). Insulin- and IGF-1-induced vasorelaxant responses in the three groups were evaluated by using isolated aortic rings, with or without endothelial denudation, in organ baths. Possible roles of phosphatidylinositol 3-kinase (PI3K) and nitric oxide synthase (NOS) involved in the NO-dependent vasorelaxation were examined by adding selective inhibitors. The role of superoxide was also clarified by adding superoxide dismutase (SOD). In addition, the endothelium-independent vascular responses to sodium nitroprusside (SNP), a NO donor, were examined. The insulin- and IGF-1-induced vasorelaxation was significantly (P < 0.05) decreased in the SHR group compared with the WKY group. This decreased response in SHR was improved by exercise. These vasorelaxant responses among the three groups became similar after endothelial denudation and pretreatment with the PI3K inhibitor, NOS inhibitor or SOD. Also, no difference among groups was found in the SNP-induced vasorelaxation. We concluded that a single bout of aerobic exercise acutely improves insulin- and IGF-1-mediated vasorelaxation in an endothelium-dependent manner in hypertensive rats.
Ai-Lun Yang; Chien-Kuei Yeh; Chia-Ting Su; Chia-Wen Lo; Ko-Long Lin; Shin-Da Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-05
Journal Detail:
Title:  Experimental physiology     Volume:  95     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  622-9     Citation Subset:  IM    
Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, 91 Hsueh-Shih Road,Taichung, 40202, Taiwan.
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MeSH Terms
Androstadienes / pharmacology
Endothelium, Vascular / drug effects,  physiopathology
Hypertension / physiopathology*
Insulin / pharmacology*
Insulin-Like Growth Factor I / pharmacology*
NG-Nitroarginine Methyl Ester / pharmacology
Nitroprusside / pharmacology
Physical Conditioning, Animal*
Rats, Inbred SHR
Rats, Inbred WKY
Superoxide Dismutase / metabolism
Vasodilation / drug effects,  physiology*
Reg. No./Substance:
0/Androstadienes; 11061-68-0/Insulin; 15078-28-1/Nitroprusside; 19545-26-7/wortmannin; 50903-99-6/NG-Nitroarginine Methyl Ester; 67763-96-6/Insulin-Like Growth Factor I; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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