Document Detail

Aerobic endurance exercise improves executive functions in depressed patients.
MedLine Citation:
PMID:  14628975     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Aerobic endurance exercise has been shown to improve higher cognitive functions such as executive control in healthy subjects. We tested the hypothesis that a 30-minute individually customized endurance exercise program has the potential to enhance executive functions in patients with major depressive disorder. METHOD: In a randomized within-subject study design, 24 patients with DSM-IV major depressive disorder and 10 healthy control subjects performed 30 minutes of aerobic endurance exercise at 2 different workload levels of 40% and 60% of their predetermined individual 4-mmol/L lactic acid exercise capacity. They were then tested with 4 standardized computerized neuropsychological paradigms measuring executive control functions: the task switch paradigm, flanker task, Stroop task, and GoNogo task. Performance was measured by reaction time. Data were gathered between fall 2000 and spring 2002. RESULTS: While there were no significant exercise-dependent alterations in reaction time in the control group, for depressive patients we observed a significant decrease in mean reaction time for the congruent Stroop task condition at the 60% energy level (p = .016), for the incongruent Stroop task condition at the 40% energy level (p = .02), and for the GoNogo task at both energy levels (40%, p = .025; 60%, p = .048). The exercise procedures had no significant effect on reaction time in the task switch paradigm or the flanker task. CONCLUSION: A single 30-minute aerobic endurance exercise program performed by depressed patients has positive effects on executive control processes that appear to be specifically subserved by the anterior cingulate.
Sabine Kubesch; Volker Bretschneider; Roland Freudenmann; Niels Weidenhammer; Manfred Lehmann; Manfred Spitzer; Georg Grön
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  64     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-02-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1005-12     Citation Subset:  IM    
Department of Psychiatry, University of Ulm, Ulm, Germany.
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MeSH Terms
Attention / physiology*
Cognition Disorders / diagnosis,  physiopathology,  psychology,  rehabilitation*
Depressive Disorder, Major / diagnosis,  physiopathology,  psychology,  rehabilitation*
Discrimination Learning / physiology*
Exercise / physiology,  psychology*
Exercise Test
Heart Rate / physiology
Lactic Acid / blood
Neuropsychological Tests*
Physical Endurance* / physiology
Reaction Time / physiology*
Reg. No./Substance:
50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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