| Aerobic degradation of tylosin in cattle, chicken, and swine excreta. | |
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MedLine Citation:
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PMID: 12865047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tylosin, a fermentation-derived macrolide antibiotic, was tested to determine its aerobic degradation rate in cattle, chicken, and swine excreta. For chicken, excreta from a hen administered 14C-tylosin as part of a metabolism study were used. For cattle and swine, 14C-tylosin was added to control excreta. The formation of 14C volatile breakdown products and 14CO2 was not observed throughout the study. Material balance for the carbon-14 label ranged between 94% and 104%. Initial, day-0, concentrations of tylosin-A averaged 119.52+/-4.39, 35.01+/-1.34, and 62.82+/-2.11 microg/g (dry weight basis) for cattle, chicken, and swine excreta samples, respectively. After 30 days, samples averaged 4.16+/-0.69 and 4.11+/-0.69 microg/g tylosin-A in cattle and swine excreta, respectively. No residues of tylosin-A or its factors were apparent in the chicken excreta samples after 30 days of incubation. In each case, tylosin declined to less than 6.5% of the initial level after 30 days. Calculated first-order half-lives under the test conditions were 6.2 days, <7.6 days, and 7.6 days for cattle, chicken, and swine excreta, respectively. The results indicate that tylosin residues degrade rapidly in animal excreta. Therefore, tylosin residues should not persist in the environment. |
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Authors:
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Jerold Scott Teeter; Roger D Meyerhoff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Environmental research Volume: 93 ISSN: 0013-9351 ISO Abbreviation: Environ. Res. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-07-16 Completed Date: 2003-09-02 Revised Date: 2006-10-30 |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: United States |
Other Details:
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Languages: eng Pagination: 45-51 Citation Subset: IM |
Affiliation:
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Lilly Research Laboratories, A Division of Eli Lilly and Company, 2001 West Main Street, Drop Code GL45, Greenfield, IN 46140, USA. jsteeter@lilly.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / metabolism* Carbon Radioisotopes / metabolism Cattle Chickens Drug Residues / metabolism* Feces / chemistry Female Soil Pollutants / metabolism Swine Tylosin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Carbon Radioisotopes; 0/Soil Pollutants; 1401-69-0/Tylosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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