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Aerobic Exercise Training Attenuates Obesity-Related Hypogonadism in Male Rats.
MedLine Citation:
PMID:  23299768     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hypogonadism is associated with obesity and other features of metabolic syndrome in males. PURPOSE: The purpose of this study was to compare lean and obese male Zucker rats on their reproductive endocrine function in response to aerobic exercise training. METHODS: Lean (Fa/Fa) and obese (fa/fa) male Zucker rats at 2 months of age were randomly assigned to a sedentary and an aerobic exercise training group (lean sedentary: n = 7, lean exercise: n = 8, obese sedentary, n = 7, obese exercise: n = 7). The exercise group walked on a rat treadmill, starting at 10 m/min for 20 min and building up to 20 m/min for 60 min, 5 times per week for 8 weeks. Serum levels of total and free testosterone, and testicular levels of testosterone, as well as epididymal and inguinal adipose tissue monocyte chemotactic protein 1 (MCP-1) release levels were measured. RESULTS: There were significant obesity and exercise interactions on serum levels of total and free testosterone, and testicular levels of testosterone (all P < 0.05). Compared to lean sedentary rats, obese sedentary rats had lower serum and testicular testosterone levels (0.72- to 0.74-fold, all P < 0.001). There were no group differences between lean sedentary and lean exercise rats on serum and testicular testosterone levels. However, compared to the obese sedentary group, the obese exercise group had higher serum and testicular testosterone levels (1.37- to 1.47-fold, all P < 0.05). In the whole cohort, serum and testicular testosterone levels were inversely related to epididymal adipose tissue MCP-1 secretion (r = -0.40 to r = -0.45, all P < 0.05). CONCLUSIONS: Our results support that aerobic exercise training could improve severe obesityrelated hypogonadism in male Zucker rats. The underlying mechanism needs to be further clarified.
Authors:
Tongjian You; Beth L Disanzo; Nicole C Arsenis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA 2Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, The State University of New York at Buffalo, Buffalo, NY 3Department of Nursing, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA.
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