Document Detail

Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease.
MedLine Citation:
PMID:  20847403     Owner:  NLM     Status:  MEDLINE    
Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise for physical health are well-documented, exercise effects on cognition have not been examined for older adults with poor glucose regulation associated with prediabetes and early T2DM. Using a randomized controlled design, twenty-eight adults (57-83 y old) meeting 2-h tolerance test criteria for glucose intolerance completed 6 months of aerobic exercise or stretching, which served as the control. The primary cognitive outcomes included measures of executive function (Trails B, Task Switching, Stroop, Self-ordered Pointing Test, and Verbal Fluency). Other outcomes included memory performance (Story Recall, List Learning), measures of cardiorespiratory fitness obtained via maximal-graded exercise treadmill test, glucose disposal during hyperinsulinemic-euglycemic clamp, body fat, and fasting plasma levels of insulin, cortisol, brain-derived neurotrophic factor, insulin-like growth factor-1, amyloid-β (Aβ40 and Aβ42). Six months of aerobic exercise improved executive function (MANCOVA, p=0.04), cardiorespiratory fitness (MANOVA, p=0.03), and insulin sensitivity (p=0.05). Across all subjects, 6-month changes in cardiorespiratory fitness and insulin sensitivity were positively correlated (p=0.01). For Aβ42, plasma levels tended to decrease for the aerobic group relative to controls (p=0.07). The results of our study using rigorous controlled methodology suggest a cognition-enhancing effect of aerobic exercise for older glucose intolerant adults. Although replication in a larger sample is needed, our findings potentially have important therapeutic implications for a growing number of adults at increased risk of cognitive decline.
Laura D Baker; Laura L Frank; Karen Foster-Schubert; Pattie S Green; Charles W Wilkinson; Anne McTiernan; Brenna A Cholerton; Stephen R Plymate; Mark A Fishel; G Stennis Watson; Glen E Duncan; Pankaj D Mehta; Suzanne Craft
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  22     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-18     Completed Date:  2011-03-09     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  569-79     Citation Subset:  IM    
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MeSH Terms
Alzheimer Disease / etiology*
Amyloid beta-Peptides / blood
Brain-Derived Neurotrophic Factor / blood
Cognition Disorders / etiology*,  rehabilitation*
Executive Function / physiology
Exercise Therapy / methods*
Follow-Up Studies
Glucose Clamp Technique / methods
Glucose Intolerance / complications*,  rehabilitation
Heart Rate / physiology
Insulin-Like Growth Factor I / metabolism
Memory / physiology
Middle Aged
Neuropsychological Tests
Oxygen Consumption / physiology
Risk Factors
Grant Support
Reg. No./Substance:
0/Amyloid beta-Peptides; 0/Brain-Derived Neurotrophic Factor; 67763-96-6/Insulin-Like Growth Factor I

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