| Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease. | |
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MedLine Citation:
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PMID: 20847403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise for physical health are well-documented, exercise effects on cognition have not been examined for older adults with poor glucose regulation associated with prediabetes and early T2DM. Using a randomized controlled design, twenty-eight adults (57-83 y old) meeting 2-h tolerance test criteria for glucose intolerance completed 6 months of aerobic exercise or stretching, which served as the control. The primary cognitive outcomes included measures of executive function (Trails B, Task Switching, Stroop, Self-ordered Pointing Test, and Verbal Fluency). Other outcomes included memory performance (Story Recall, List Learning), measures of cardiorespiratory fitness obtained via maximal-graded exercise treadmill test, glucose disposal during hyperinsulinemic-euglycemic clamp, body fat, and fasting plasma levels of insulin, cortisol, brain-derived neurotrophic factor, insulin-like growth factor-1, amyloid-β (Aβ40 and Aβ42). Six months of aerobic exercise improved executive function (MANCOVA, p=0.04), cardiorespiratory fitness (MANOVA, p=0.03), and insulin sensitivity (p=0.05). Across all subjects, 6-month changes in cardiorespiratory fitness and insulin sensitivity were positively correlated (p=0.01). For Aβ42, plasma levels tended to decrease for the aerobic group relative to controls (p=0.07). The results of our study using rigorous controlled methodology suggest a cognition-enhancing effect of aerobic exercise for older glucose intolerant adults. Although replication in a larger sample is needed, our findings potentially have important therapeutic implications for a growing number of adults at increased risk of cognitive decline. |
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Authors:
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Laura D Baker; Laura L Frank; Karen Foster-Schubert; Pattie S Green; Charles W Wilkinson; Anne McTiernan; Brenna A Cholerton; Stephen R Plymate; Mark A Fishel; G Stennis Watson; Glen E Duncan; Pankaj D Mehta; Suzanne Craft |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of Alzheimer's disease : JAD Volume: 22 ISSN: 1875-8908 ISO Abbreviation: J. Alzheimers Dis. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2011-03-09 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 569-79 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. ldbaker@uw.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00220441 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / etiology* Amyloid beta-Peptides / blood Brain-Derived Neurotrophic Factor / blood Cognition Disorders / etiology*, rehabilitation* Executive Function / physiology Exercise* Exercise Therapy / methods* Female Follow-Up Studies Glucose Clamp Technique / methods Glucose Intolerance / complications*, rehabilitation Heart Rate / physiology Humans Insulin-Like Growth Factor I / metabolism Male Memory / physiology Middle Aged Neuropsychological Tests Oxygen Consumption / physiology Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR025015-03/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Peptides; 0/Brain-Derived Neurotrophic Factor; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
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