| Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex. | |
| | |
MedLine Citation:
|
PMID: 20692647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Exercise has recently been suggested as an attractive alternative to pharmacotherapy for treating drug addiction. The goal of this study was to determine, using an animal model, whether aerobic exercise may block reinstatement of cocaine-seeking and its underlying neurobiology (i.e., neuronal signaling in the prefrontal cortex). METHODS: Following acquisition and 10 days of 24-hour access to cocaine (1.5 mg/kg/infusion) or saline under a discrete trial procedure (four infusions/hr), rats began a 14-day abstinence period. During this period, rats were either given access to a running-wheel for 2-hours each day or placed in similar boxes with the wheel locked. Cocaine-seeking was assessed following the 14th day of abstinence using a within-session extinction/cue-induced reinstatement procedure. Neuronal activity was assessed by examining phosphorylated levels of extracellular signal-regulated kinase (pERK) using Western blot analysis. RESULTS: Wheel running reduced cocaine-seeking during both extinction and reinstatement. Cocaine-seeking was positively associated with pERK levels in the prefrontal cortex. Although pERK levels were not different among saline controls, in the cocaine group, pERK levels were significantly decreased by exercise. CONCLUSIONS: Aerobic exercise may reduce relapse vulnerability by preventing the increase in cocaine-seeking and associated neuroadaptations in the prefrontal cortex that develop over an abstinence period. |
| | |
Authors:
|
Wendy J Lynch; Kristen B Piehl; Glen Acosta; Alexis B Peterson; Scott E Hemby |
Related Documents
:
|
12669257 - Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferatio... 8423757 - Exercise training alters feed efficiency and body composition in iron deficient rats. 15475607 - Physical exercise decreases neuronal activity in the posterior hypothalamic area of spo... 3556607 - Effects of exercise on longevity of rats. 8640997 - Effects of diuretic therapy on the development of tolerance to nitroglycerin and exerci... 18420757 - The role of exercise dependence for the relationship between exercise behavior and eati... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-08 |
Journal Detail:
|
Title: Biological psychiatry Volume: 68 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: 2011-02-09 Revised Date: 2011-10-17 |
Medline Journal Info:
|
Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
|
Languages: eng Pagination: 774-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA. wlynch@virginia.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Addictive / prevention & control* Cocaine / administration & dosage, adverse effects* Cocaine-Related Disorders / prevention & control* Extinction, Psychological Extracellular Signal-Regulated MAP Kinases / metabolism* Male Physical Conditioning, Animal / psychology* Prefrontal Cortex / drug effects, metabolism* Rats Recurrence / prevention & control Self Administration |
| Grant Support | |
ID/Acronym/Agency:
|
R01 DA024716-01/DA/NIDA NIH HHS; R01 DA024716-03S1A1/DA/NIDA NIH HHS; R01DA024716/DA/NIDA NIH HHS; R01DA024716-S1/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
50-36-2/Cocaine; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A meta-analysis of cytokines in Alzheimer's disease.
Next Document: Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment.