Document Detail


Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex.
MedLine Citation:
PMID:  20692647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Exercise has recently been suggested as an attractive alternative to pharmacotherapy for treating drug addiction. The goal of this study was to determine, using an animal model, whether aerobic exercise may block reinstatement of cocaine-seeking and its underlying neurobiology (i.e., neuronal signaling in the prefrontal cortex).
METHODS: Following acquisition and 10 days of 24-hour access to cocaine (1.5 mg/kg/infusion) or saline under a discrete trial procedure (four infusions/hr), rats began a 14-day abstinence period. During this period, rats were either given access to a running-wheel for 2-hours each day or placed in similar boxes with the wheel locked. Cocaine-seeking was assessed following the 14th day of abstinence using a within-session extinction/cue-induced reinstatement procedure. Neuronal activity was assessed by examining phosphorylated levels of extracellular signal-regulated kinase (pERK) using Western blot analysis.
RESULTS: Wheel running reduced cocaine-seeking during both extinction and reinstatement. Cocaine-seeking was positively associated with pERK levels in the prefrontal cortex. Although pERK levels were not different among saline controls, in the cocaine group, pERK levels were significantly decreased by exercise.
CONCLUSIONS: Aerobic exercise may reduce relapse vulnerability by preventing the increase in cocaine-seeking and associated neuroadaptations in the prefrontal cortex that develop over an abstinence period.
Authors:
Wendy J Lynch; Kristen B Piehl; Glen Acosta; Alexis B Peterson; Scott E Hemby
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-08
Journal Detail:
Title:  Biological psychiatry     Volume:  68     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-02-09     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  774-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Addictive / prevention & control*
Cocaine / administration & dosage,  adverse effects*
Cocaine-Related Disorders / prevention & control*
Extinction, Psychological
Extracellular Signal-Regulated MAP Kinases / metabolism*
Male
Physical Conditioning, Animal / psychology*
Prefrontal Cortex / drug effects,  metabolism*
Rats
Recurrence / prevention & control
Self Administration
Grant Support
ID/Acronym/Agency:
R01 DA024716/DA/NIDA NIH HHS; R01DA024716/DA/NIDA NIH HHS; R01DA024716-S1/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases; I5Y540LHVR/Cocaine
Comments/Corrections

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