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Aerobic Exercise Alters Skeletal Muscle Molecular Responses to Resistance Exercise.
MedLine Citation:
PMID:  22460475     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: This study assessed the influence of an acute aerobic exercise bout on molecular responses to subsequent resistance exercise. METHODS: Nine physically active men performed ∼45 min one-legged cycle ergometry exercise, and 4 × 7 maximal concentric-eccentric knee extensions for each leg 6 hrs later. Thus, one limb was subjected to aerobic and resistance exercise (AE+RE), and the contralateral limb to resistance exercise (RE) only. Knee extensor peak power was determined. Biopsies were obtained from m.vastus lateralis before, 15 min and 3 hrs after resistance exercise. Analysis determined glycogen content, mRNA-levels (vascular endothelial growth factor; VEGF, peroxisome proliferator-activated receptor-γ coactivator-1; PGC-1α, muscle RING-finger protein-1; MuRF-1, atrogin-1, myostatin) and phosphorylated proteins (mammalian target of rapamyacin; mTOR, p70S6 kinase; p70S6K, ribosomal protein S6; rpS6, eukaryotic elongation factor 2; eEF2). RESULTS: Peak power was similar in AE+RE and RE. After resistance exercise, the time-course of glycogen utilization and protein signaling was similar across legs. However, phosphorylation of mTOR and p70S6K was elevated in AE+RE vs. RE (main effect P < 0.05). VEGF and PGC-1α was higher in AE+RE than RE at PRE and POST1 (P < 0.05). Myostatin was lower in AE+RE vs. RE at PRE and POST1 (P < 0.05), and downregulated in RE after resistance exercise. Atrogin-1 was higher in AE+RE than RE at PRE and POST1 (P < 0.05), and decreased following resistance exercise in AE+RE. MuRF-1 was similar across legs. No difference for any marker was evident at POST2. CONCLUSION: These results suggest that acute aerobic exercise alters molecular events regulating muscle protein turnover during the early recovery period from subsequent resistance exercise.
Authors:
Tommy R Lundberg; Rodrigo Fernandez-Gonzalo; Thomas Gustafsson; Per A Tesch
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-28
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Health Sciences, Mid Sweden University, Östersund, Sweden. 2Institute of Biomedicine (IBIOMED), University of León, León, Spain. 3Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden. 4Department of Laboratory Medicine, Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
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