Document Detail


Adynamic bone in patients with chronic kidney disease.
MedLine Citation:
PMID:  18337716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adynamic bone in patients with chronic kidney disease (CKD) is a clinical concern because of its potential increased risk for fracture and cardiovascular disease (CVD). Prevalence rates for adynamic bone are reportedly increased, although the variance for its prevalence and incidence is large. Differences in its prevalence are largely attributed to classification and population differences, the latter of which constitutes divergent groups of elderly patients having diabetes and other comorbidities that are prone to low bone formation. Most patients have vitamin D deficiency and the active form, 1,25-dihydroxyvitamin D, invariably decreases to very low levels during CKD progression. Fortunately, therapy with vitamin D receptor activators (VDRAs) appears to be useful in preventing bone loss, in part, by its effect to stimulate bone formation and in decreasing CVD morbidity, and should be considered as essential therapy regardless of bone turnover status. Future studies will depend on assessing cardiovascular outcomes to determine whether the risk/reward profile for complications related to VDRA and CKD is tolerable.
Authors:
D L Andress
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-03-12
Journal Detail:
Title:  Kidney international     Volume:  73     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1345-54     Citation Subset:  IM    
Affiliation:
Division of Nephrology, University of Washington, Seattle, Washington, USA. dennis.andress@abbott.com
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Bone Diseases / diagnosis*,  drug therapy,  epidemiology,  etiology*
Chronic Disease
Humans
Kidney Diseases / complications*
Osteoblasts / pathology
Osteogenesis*
Prevalence
Prognosis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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