Document Detail


Adverse side effects associated with prednisone in the treatment of patients with oral inflammatory ulcerative diseases.
MedLine Citation:
PMID:  6590608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic glucocorticoids in the form of prednisone have been effective in reducing signs and symptoms in a variety of acute and chronic oral inflammatory diseases. In the 101 patients prospectively studied, the benefits from prednisone treatment far outweighed the adverse side effects, which occurred in 61 patients. However, none of the adverse side effects was severe enough to require cessation of the prednisone. The adverse effects, which could be minimized by reducing the dosage in most instances, were primarily related to treatment that persisted for more than two weeks. Fluid retention or bloating was the most common symptom, and insomnia was the chief side effect in those patients receiving short-term treatment (less than two weeks). Blood sugar, blood pressure, weight, and white blood cell counts were not meaningfully altered. Variables in patients' drug response and side effects precluded formulation of precise prednisone dosages that would allow predictive outcomes.
Authors:
F Lozada; S Silverman; C Migliorati
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Dental Association (1939)     Volume:  109     ISSN:  0002-8177     ISO Abbreviation:  J Am Dent Assoc     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-10-04     Completed Date:  1984-10-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503060     Medline TA:  J Am Dent Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-70     Citation Subset:  D; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Glucose / analysis
Blood Pressure / drug effects
Body Fluids / drug effects
Female
Humans
Male
Middle Aged
Mouth Diseases / drug therapy*
Prednisone / administration & dosage,  adverse effects*,  therapeutic use
Prospective Studies
Time Factors
Ulcer / drug therapy
Grant Support
ID/Acronym/Agency:
DE 05890-01/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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