Document Detail

Adverse reactions to propranolol, a non-selective beta-adrenergic blocking agent in hypertensive patients--a collaborative study.
MedLine Citation:
PMID:  8449549     Owner:  NLM     Status:  MEDLINE    
Propranolol, a nonselective beta-adrenergic blocking agent, although prescribed frequently, has not been monitored for its adverse reactions in Indian population. A collaborative ADR monitoring study was planned in 2661 hypertensive patients. Exclusion criteria were associated circulatory insufficiency, heart block, left ventricular failure, diabetic mellitus and airway obstruction. The incidence of ADR was 2.1%, which is lower than reported incidence of 8.7 to 43.7 percent in other studies. This could be attributed to improper selection of patients, differences in methodology of monitoring, or to racial variation. In the present study ADR of fatigue (1.1%), dizziness (0.4%) and headache (0.2%) constituted the bulk. Additional reaction of pain in chest (0.2%), heart block (0.1%), hypoglycemia (0.1%), loss of libido (0.1%) and shock (0.03%), were also observed.
K C Garg; K C Singhal; S Kumar; A Lal
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  37     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-04-12     Completed Date:  1993-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
Department of Medicine, Maulana Azad Medical College, New Delhi.
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MeSH Terms
Adverse Drug Reaction Reporting Systems
Follow-Up Studies
Hypertension / drug therapy*
Middle Aged
Propranolol / adverse effects*
Prospective Studies
Reg. No./Substance:

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