Document Detail


Adverse reactions to practolol: some observations on the possible relevence to immune mechanisms.
MedLine Citation:
PMID:  80139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HLA antigen frequencies were determined in patients who had suffered adverse reaction to the beta-adrenergic blocking agent, practolol. No statistically significant differences were observed between these patients and control groups. The latter were selected to include two separate groups, normal random healthy population controls, and controls who had taken practolol with no apparent adverse effects. Patients suffering from the very severe form of reaction, sclerosing peritonitis, were analysed separately from those with other lesion e.g. ocular symptoms, but did not show any significant differences. Altered HLA antigen frequencies were observed for those control patients whose primary diagnosis was hypertension but this was considered to be due to selection bias.
Authors:
H M Dick; P Wright; C M Chapman; F J Zacharias; J T Nicholls
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergy     Volume:  33     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Epitopes
Eye Diseases / chemically induced,  immunology
Gene Frequency
Genes, MHC Class II*
HLA Antigens*
Humans
Peritonitis / chemically induced,  immunology
Practolol / adverse effects*,  therapeutic use
Sclerosis
Chemical
Reg. No./Substance:
0/Epitopes; 0/HLA Antigens; 6673-35-4/Practolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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