Document Detail

Adverse reactions to food additives.
MedLine Citation:
PMID:  8214803     Owner:  NLM     Status:  MEDLINE    
Food additives can induce a wide range of adverse reactions in sensitive individuals. A prevalence of 0.03% to 0.23% is estimated. The complexity of the different pathophysiologic mechanisms possibly involved in the allergic (immunologic) or in the intolerant (nonimmunologic) reactions to food additives continues to create great difficulties in the understanding of such conditions. From the clinical point of view it is useful to make a distinction between an intolerance reaction and intolerance provocation. The pathogenic mechanisms of adverse reactions to the azo dye tartrazine and to sulfite preservatives are discussed briefly. Due to the lack of reliable skin or in vitro tests, the diagnosis of an intolerance to food additives is still based on placebo-controlled oral provocation tests. Two typical cases of a "restaurant syndrome" due to sulfite allergy or sensitivity are described, as well as a case of disulfite-induced urticaria-vasculitis and a case of anaphylactoid purpura associated with tartrazine and benzoates.
B Wüthrich
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of allergy     Volume:  71     ISSN:  0003-4738     ISO Abbreviation:  Ann Allergy     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-19     Completed Date:  1993-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372346     Medline TA:  Ann Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
Department of Dermatology, University Hospital Zürich, Switzerland.
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MeSH Terms
Anaphylaxis / chemically induced,  diagnosis,  epidemiology
Benzoates / adverse effects
Drug Hypersensitivity / diagnosis,  epidemiology,  etiology
Food Additives / adverse effects*
Food Hypersensitivity / diagnosis,  epidemiology,  etiology
Immunoglobulin E / analysis
Middle Aged
Purpura / chemically induced,  diagnosis,  epidemiology
Sulfites / adverse effects
Tartrazine / adverse effects
Urticaria / chemically induced,  diagnosis,  epidemiology
Vasculitis / chemically induced,  diagnosis,  epidemiology
Reg. No./Substance:
0/Benzoates; 0/Food Additives; 0/Sulfites; 1934-21-0/Tartrazine; 37341-29-0/Immunoglobulin E

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