Document Detail

Adverse reactions to duloxetine in depression.
MedLine Citation:
PMID:  21545241     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Untreated or inadequately treated depression is the largest risk factor for suicide. However, treatment with different antidepressants can have considerable adverse effects, including the increase of the frequency of suicidal thoughts and behavior. This review summarizes the frequency and severity of adverse events observed during the treatment of depression with duloxetine and considers their relevance to clinical practice.
AREAS COVERED: A comprehensive review of the literature was conducted using PubMed and Medline databases listing data published until December 2010. Articles describing safety and tolerability of duloxetine were selected and reference lists of these articles were scrutinized for further relevant papers. In addition, US and EU Summaries of Product Characteristics were studied.
EXPERT OPINION: Treatment with duloxetine was associated with mild to moderate adverse events; sexual dysfunction, nausea, headache, dry mouth, somnolence and dizziness being the most frequent among them. No increase in death from suicide and suicidal thoughts and behavior were detected as compared to placebo. So as to avoid discontinuation syndrome as a consequence of abrupt withdrawal of duloxetine, 2 weeks tapering has been recommended before discontinuation. Overall, duloxetine was found to be well tolerated and can be safely administered even in older patients and in those with concomitant illnesses.
Istvan Bitter; Dora Filipovits; Pal Czobor
Publication Detail:
Type:  Journal Article; Review     Date:  2011-05-05
Journal Detail:
Title:  Expert opinion on drug safety     Volume:  10     ISSN:  1744-764X     ISO Abbreviation:  Expert Opin Drug Saf     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-02-15     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101163027     Medline TA:  Expert Opin Drug Saf     Country:  England    
Other Details:
Languages:  eng     Pagination:  839-50     Citation Subset:  IM    
Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary.
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MeSH Terms
Antidepressive Agents / adverse effects*
Depression / drug therapy*
Randomized Controlled Trials as Topic
Thiophenes / adverse effects*,  pharmacology,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents; 0/Thiophenes; O5TNM5N07U/duloxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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